{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T02:54:17Z","timestamp":1768704857857,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003062","name":"Erciyes \u00dcniversitesi","doi-asserted-by":"publisher","award":["TYL\u20108365"],"award-info":[{"award-number":["TYL\u20108365"]}],"id":[{"id":"10.13039\/501100003062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Doxorubicin (Dox) may induce loss of follicles, resulting in the depletion of ovarian reserve and consequent premature ovarian failure. Selenium (Se) is an oligoelement with fundamental biological features and is among the most common chemical inhibitor compounds. The present study describes the curative effects of dietary supplementation with different Se doses on Dox\u2010induced ovarian damage in rats. In this study, 64 adult female Wistar rats were randomly separated into eight groups: Control group, Dox group (5\u2009mg\/kg intraperitoneal [i.p.]), low\u2010dose Se (0.5\u2009mg\/kg i.p.), middle dose Se (1\u2009mg\/kg i.p.), high dose (Se 2\u2009mg\/kg i.p.), Dox\u2009+\u2009low\u2010dose Se group (0.5\u2009mg\/kg i.p.), Dox\u2009+\u2009middle dose Se (1\u2009mg\/kg i.p.), and Dox\u2009+\u2009high\u2010dose Se group (2\u2009mg\/kg i.p.). After the experiment, ovarian follicles were counted, and Antim\u00fcllerian hormone, interleukin 1 beta,\u00a0tumor necrosis factor alpha,\u00a0and caspase\u20103 expression were determined. Levels of malondialdehyde, superoxide dismutase, catalase, and glutathione peroxidase\u00a0were biochemically measured in ovarian tissue. Dox caused ovarian injury, as evidenced by significant changes in ovarian markers, histological abnormalities, and the debilitation of antioxidant defense mechanisms. Furthermore, Dox therapy significantly changed the expression of inflammatory and apoptotic markers. Dox\u2009+\u20091\u2009mg Se with various saturations was studied, and this study demonstrated both histopathological and follicular reserve and more protective features. 1\u2009mg Se pretreatment improved Dox\u2010induced ovarian toxicity through alleviating the antioxidant mechanism, decreasing inflammation and apoptosis, and restoring ovarian architecture. As a result, our findings indicate that 1\u2009mg Se is a promising therapeutic agent for the prevention of ovarian damage associated with Dox.<\/jats:p>","DOI":"10.1002\/jbt.23522","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T14:43:07Z","timestamp":1693492987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Studies on the ameliorative potential of dietary supplemented different dose of selenium on doxorubicin\u2010induced ovarian damage in rat"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4638-6116","authenticated-orcid":false,"given":"Ozge","family":"Cengiz Mat","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Erciyes University Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6861-416X","authenticated-orcid":false,"given":"Pinar","family":"Alisan Suna","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Erciyes University Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0369-1022","authenticated-orcid":false,"given":"Munevver","family":"Baran","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Basic Science, Faculty of Pharmacy Erciyes University Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4289-2305","authenticated-orcid":false,"given":"Ayse","family":"Ceyhan","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Erciyes University Kayseri Turkey"},{"name":"Tokat Gaziosmanpa\u015fa University Vocational School of Health Services Tokat Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0541-8372","authenticated-orcid":false,"given":"Arzu","family":"Yay","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Erciyes University Kayseri Turkey"},{"name":"Genome and Stem Cell Center (GENKOK) Erciyes University Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"issue":"7","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133985","volume":"10","author":"Azarbaijani A. 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