{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:33:00Z","timestamp":1755225180966,"version":"3.43.0"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myocardial infarction (MI) is a common type of ischemic heart disease that affects millions of people worldwide. In recent times, nanotechnology has become a very promising field with immense applications. The current exploration was conducted to synthesize the chitosan\u2010sodium alginate\u2010polyethylene glycol\u2010Ally isothiocyanate nanocomposites (CSP\u2010AIso\u2010NCs) and evaluate their beneficial roles against the isoproterenol (ISO)\u2010induced MI in rats. The CSP\u2010AIso\u2010NCs were prepared and characterized by several characterization techniques. The MI was initiated in the rats by the administration of 85\u2009mg\/kg of ISO for 2 days and treated with 10 and 20\u2009mg\/kg of CSP\u2010AIso\u2010NCs for 1 month. The changes in heart weight and bodyweight were measured. The cardiac function markers were assessed with echocardiography. The lipid profiles, Na+, K+, and Ca<jats:sup>2+<\/jats:sup> ions, cardiac biomarkers, antioxidant parameters, and inflammatory cytokines were assessed using corresponding assay kits. The histopathological study was done on the heart tissues. The UV spectral analysis revealed the maximum peak at 208\u2009nm, which confirms the formation of CSP\u2010AIso\u2010NCs. The FT\u2010IR analysis revealed the occurrence of different functional groups, and the crystallinity of the CSP\u2010AIso\u2010NCs was proved by the XRD analysis. DLS analysis indicated the size of the CSP\u2010AIso\u2010NCs at 146.50\u2009nm. The CSP\u2010AIso\u2010NCs treatment increased the bodyweight and decreased the HW\/BW ratio in the MI rats. The status of lipids was reduced, and HDL was elevated in the CSP\u2010AIso\u2010NCs administered to MI rats. CSP\u2010AIso\u2010NCs decreased the LVEDs, LVEDd, and NT\u2010proBNP and increased the LVEF level. The oxidative stress markers were decreased, and the antioxidants were increased by the CSP\u2010AIso\u2010NCs treatment in the MI rats. The Na+ and Ca+ ions were reduced, and the K+ ions were increased by the CSP\u2010AIso\u2010NCs. The interleukin\u20101\u03b2 and tumor necrosis factor\u2010\u03b1 were also depleted, and Nrf\u20102 was improved in the CSP\u2010AIso\u2010NCs administered to MI rats. The histological study revealed the ameliorative effects of CSP\u2010AIso\u2010NCs. Overall, our outcomes revealed that the CSP\u2010AIso\u2010NCs are effective against the ISO\u2010induced MI rats. Hence, it could be a hopeful therapeutic nanomedicine for MI treatment.<\/jats:p>","DOI":"10.1002\/jbt.23531","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T08:19:25Z","timestamp":1695111565000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chitosan\u2010sodium alginate\u2010polyethylene glycol\u2010Ally isothiocyante nanocomposites ameliorates isoproterenol\u2010induced myocardial infarction in rats"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3370-6733","authenticated-orcid":false,"given":"Lei","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Henan Provincial Chest Hospital Zhengzhou University Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingchao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Henan Provincial Chest Hospital Zhengzhou University Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Henan Provincial Chest Hospital Zhengzhou University Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangxu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Henan Provincial Chest Hospital Zhengzhou University Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.052"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02031"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.199"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30677-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232112906"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.07.014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.03.037"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.11.021"},{"key":"e_1_2_8_10_1","volume":"117","author":"Pasupathy S.","year":"2017","journal-title":"Circulation"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5041\/RMMJ.10401"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.08.009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S250872"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano12020186"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12112499"},{"key":"e_1_2_8_16_1","first-page":"1","volume":"2019","author":"Jiang T.","year":"2019","journal-title":"Oxid. 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