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Due to the prevalence of hypertension (one of the major risk factors of cardiovascular disease [CVD]) in the population, it is necessary to explore the adverse effect of BPA under hypertension associated pathogenic milieu. The current study exposed the N\u03c9\u2010nitro\u2010<jats:sc>l<\/jats:sc>\u2010arginine methyl ester (L\u2010NAME) induced hypertensive Wistar rats to low dose BPA (50\u2009\u03bcg\/kg) for 30 days period. In tissue samples immunohistochemistry, real\u2010time quantitative polymerase chain reaction and enzymatic assays were conducted. Moreover, studies on primary kidney cell culture were employed to explore the impact of low dose of BPA exposure at nanomolar level (20\u221280\u2009nM range) on renal cells through various fluorescence assays. The observed results illustrate that BPA exposure potentiates\/aggravates hypertension induced tissue abnormalities (renal fibrosis), oxidative stress (ROS generation), elevated angiotensin\u2010converting enzyme activity, malfunction of the antioxidant and tricarboxylic acid cycle enzymes, tissue lipid abnormalities and inflammatory factor expression (both messenger RNA and protein level of TNF\u2010\u03b1 and IL\u20106). Further, in vitro exposure of nM levels of BPA to primary kidney cells modulates oxidative stress (both superoxide and total ROS), mitochondrial physiology (reduced mitochondrial transmembrane potential\u2014\u2206\u03c8m) and lipid peroxidation in a dose dependent manner. In addition, angiotensin II induced ROS generation was aggravated further by BPA during coexposure in kidney cells. Therefore, during risk assessment, a precise investigation on BPA exposure in hypertensive (CVD vulnerable) populations is highly suggested.<\/jats:p>","DOI":"10.1002\/jbt.23533","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T03:14:53Z","timestamp":1695006893000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Exposure to low dose of Bisphenol A (BPA) intensifies kidney oxidative stress, inflammatory factors expression and modulates Angiotensin II signaling under hypertensive milieu"],"prefix":"10.1002","volume":"38","author":[{"given":"Manigandan","family":"Nagarajan","sequence":"first","affiliation":[{"name":"Environmental Health and Toxicology Laboratory, Department of Environmental Sciences, School of Life Sciences Bharathiar University Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gobichettipalayam Balasubramaniam","family":"Maadurshni","sequence":"additional","affiliation":[{"name":"Environmental Health and Toxicology Laboratory, Department of Environmental Sciences, School of Life Sciences Bharathiar University Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3948-0155","authenticated-orcid":false,"given":"Jeganathan","family":"Manivannan","sequence":"additional","affiliation":[{"name":"Environmental Health and Toxicology Laboratory, Department of Environmental Sciences, School of Life Sciences Bharathiar University Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.23937\/2572-4061.1510021"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.125571"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c02760"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.8b00824"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1384"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-019-0558-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.07.007"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b05387"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.319"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.113639"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184382"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112772"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3082438"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30781"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2021.166296"},{"issue":"2","key":"e_1_2_10_17_1","first-page":"649","volume":"12","author":"Dong Y.","year":"2020","journal-title":"Am. 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