{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:35:07Z","timestamp":1790602507371,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dose\u2010dependent heart failure is a major complication of the clinical use of doxorubicin (Dox), one of the most potent chemotherapeutic agents. Effective adjuvant therapy is required to prevent Dox\u2010induced cardiotoxicity. Currently, plant\u2010derived exosome\u2010like nanovesicle (PELNV) has revealed their salubrious antioxidant and immunological regulating actions in various disease models. In this study, we isolated, purified and characterized\n                    <jats:italic>Beta vulgaris<\/jats:italic>\n                    \u2010derived exosome\u2010like nanovesicle (BELNV). Dox or normal saline was given to HL\u20101 cells (3\u2009\u03bcM) and 8\u2010week C57BL\/6N mice (5\u2009mg\/kg bodyweight per week for 4 weeks) to establish the in vitro and in vivo model of Dox\u2010induced cardiotoxicity. Administration of BELNV significantly alleviated chronic Dox\u2010induced cardiotoxicity in terms of echocardiographic and histological results. A reduced malondialdehyde (MDA), increased ratio of glutathione (GSH) to oxidized glutathione (GSSG) and levels of system xc\n                    <jats:sup>\u2212<\/jats:sup>\n                    and glutathione peroxidase 4 were observed, indicating that DOX\u2010stimulated ferroptosis was reversed by BELNV. Besides, the safety of BELNV was also validated since no liver, spleen, and kidney toxicity induced by BELNV was observed. These findings provide evidence that BELNV may act as a novel therapeutic biomaterial for patients undergoing adverse effects of Dox, at least partly mediated by inhibiting Dox\u2010induced ferroptosis.\n                  <\/jats:p>","DOI":"10.1002\/jbt.23540","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T07:11:00Z","timestamp":1695193860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["<i>Beta vulgaris<\/i>\n                    \u2010derived exosome\u2010like nanovesicles alleviate chronic doxorubicin\u2010induced cardiotoxicity by inhibiting ferroptosis"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5058-8397","authenticated-orcid":false,"given":"Jiejie","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7745-9288","authenticated-orcid":false,"given":"Jingye","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101394"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200507020-00001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.12.121"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1821022116"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2919"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S328723"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz139"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-02969-y"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606924"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300729"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11010087"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.04.023"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.823039"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700478"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7042801"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.660150"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S293067"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13081203"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.685434"},{"key":"e_1_2_11_21_1","first-page":"1","volume":"2019","author":"Hu X.","year":"2019","journal-title":"Oxid. 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