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Sixty\u2010three adult male albino rats were randomly assigned into nine (<jats:italic>n<\/jats:italic>\u2009=\u20097) groups. Group I: control animals, Group II was treated with 100\u2009mg\/kg KBrO<jats:sub>3<\/jats:sub>, Group III was treated with 250\u2009mg\/kg CAF, Group IV was treated with 100\u2009mg\/kg KBrO<jats:sub>3<\/jats:sub>\u2009+\u2009250\u2009mg\/kg CAF, Group V was administered with 100\u2009mg\/kg KBrO<jats:sub>3<\/jats:sub>\u2009+\u2009100\u2009mg\/kg haloperidol, Group VI was administered with 100\u2009mg\/kg KBrO<jats:sub>3<\/jats:sub>\u2009+\u200950\u2009mg\/kg NAR, Group VII was administered with 500\u2009mg\/kg CAF\u2009+\u200950\u2009mg\/kg NAR, and Group VIII was administered with 100\u2009mg\/kg KBrO<jats:sub>3<\/jats:sub>\u2009+\u2009250\u2009mg\/kg CAF\u2009+\u200950\u2009mg\/kg NAR. Finally, group IX was treated with 50\u2009mg\/kg NAR. The exposure of rats to KBrO<jats:sub>3<\/jats:sub> and CAF for 21 days induced renal dysfunction linked with Lesch\u2010Nyhan disease. NAR obliterated renal dysfunction linked with Lesch\u2010Nyhan disease by decreasing uric acid, renal malondialdehyde level, inhibiting the activities of arginase, and phosphodiesterase\u20105<jats:sup>1<\/jats:sup> (PDE\u201051) with corresponding upregulation of brain derived\u2010neurotrophic factor and its receptor (BDNF\u2010TrkB), Bcl11b, HGPRT1, and DARPP\u201032. Additionally, renal failure related to Lesch\u2010Nyhan disease was remarkably corrected by NAR as shown by the reduced activities of AChE and enzymes of ATP hydrolysis (ATPase, AMPase, and ADA) with affiliated increase in the\u00a0NO level. This study therefore validates NAR as nontoxic and effective chemotherapy against kidney\u2010related Lesch\u2010Nyhan disease by mitigating effects of toxic food additives and enzymes of ATP\u2010hydrolysis via NOS\u2013cAMP\u2013PKA and BDNF\/TrkB signaling pathways.<\/jats:p>","DOI":"10.1002\/jbt.23558","type":"journal-article","created":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T12:54:06Z","timestamp":1697979246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Naringin corrects renal failure related to Lesch\u2010Nyhan disease in a rat model via NOS\u2013cAMP\u2013PKA and BDNF\/TrkB pathways"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-9705","authenticated-orcid":false,"given":"Jacob K.","family":"Akintunde","sequence":"first","affiliation":[{"name":"Molecular Toxicology and Biomedical Research Group, Department of Biochemistry, College of Biosciences Federal University of Agriculture Abeokuta Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idowu M.","family":"Falomo","sequence":"additional","affiliation":[{"name":"Molecular Toxicology and Biomedical Research Group, Department of Biochemistry, College of Biosciences Federal University of Agriculture Abeokuta Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oreoluwa M.","family":"Akinbohun","sequence":"additional","affiliation":[{"name":"Molecular Toxicology and Biomedical Research Group, Department of Biochemistry, College of Biosciences Federal University of Agriculture Abeokuta Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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