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Conventional treatment with nonsteroidal anti\u2010inflammatory drugs has been widely utilized clinically, whereas the side effects have restricted their application. Forsythoside B has been found with anti\u2010inflammatory effects and antiapoptosis in inflammatory diseases, whereas in OA it remains poorly understood. Interleukin (IL)\u22121\u03b2 (10\u2009ng\/mL) was taken to induce an OA cell model on HC\u2010A chondrocytes and an OA rat model was constructed for in vivo experiments. Forsythoside B was adopted to treat HC\u2010A chondrocytes and OA rats. As shown by the data, Forsythoside B hampered IL\u20101\u03b2\u2010elicited rat chondrocyte apoptosis, oxidative stress, and facilitated proliferation. The profiles of inflammatory factors, NOD\u2010like receptor family pyrin domain containing 3 inflammasomes, Kelch\u2010like epichlorohydrin\u2010associated protein\u20101 (Keap1), and nuclear factor\u2010\u03baB (NF\u2010\u03baB) phosphorylation were suppressed by Forsythoside B, whereas the nuclear factor E2\u2010related factor 2 (Nrf2) and heme oxygenase\u20101 (HO\u20101) levels were promoted. Further, Forsythoside B mitigated cartilage damage and degeneration. Moreover, the oxidative stress and inflammation mediators in the cartilage tissue of OA rats were remarkably abated. Collectively, Forsythoside B hinders the NF\u2010\u03baB and Keap1\/Nrf2\/HO\u20101 pathways to curb IL\u20101\u03b2\u2010elicited OA rat oxidative stress and inflammation both in vivo and ex vivo, ameliorating OA development. All over, this study provides an underlying strategy for treating OA, which might help the clinical treatment of OA patients.<\/jats:p>","DOI":"10.1002\/jbt.23569","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T11:39:51Z","timestamp":1699529991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Forsythoside B alleviates osteoarthritis through the HMGB1\/TLR4\/NF\u2010\u03baB and Keap1\/Nrf2\/HO\u20101 pathways"],"prefix":"10.1002","volume":"38","author":[{"given":"Shujuan","family":"Li","sequence":"first","affiliation":[{"name":"Neurology Department Wuxi People Hosptial  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Department, Tongren Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Affiliated Hospital of Jiangsu University  Zhenjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tang","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Department, Tongren Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0693-7991","authenticated-orcid":false,"given":"Fang","family":"Gao","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Department, Tongren Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60802-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2016.1207206"},{"issue":"5","key":"e_1_2_9_4_1","first-page":"929","volume":"34","author":"Yu D.","year":"2016","journal-title":"Clin. 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