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Lipopolysaccharide (LPS) and D\u2010galactoamine (D\u2010GalN) were applied to establish the mouse model of LPS\/D\u2010GalN\u2010induced liver injury, and TNF\u2010\u03b1 and D\u2010Gal were used to construct an in vitro cell model, followed by treatment of sh\u2010GDF11 for analysis of liver cell proliferation. Bioinformatics analysis showed that the protective effect of sh\u2010GDF11 on ALF may be mediated by phosphatidylinositol\u20103\u2010kinase (PI3K)\/protein kinase B (Akt)\/mammalian target of rapamycin (mTOR) signaling pathway. The results of in vitro study found that sh\u2010GDF11 could promote cell proliferation and inhibit death by blocking the PI3K\/Akt\/mTOR signaling pathway. In vivo animal experiments further confirmed that sh\u2010GDF11 could suppress hepatocyte apoptosis by inhibiting the PI3K\/Akt\/mTOR signaling pathway. sh\u2010GDF11 relieved LPS\/D\u2010GalN\u2010induced ALF by blocking the PI3K\/Akt\/mTOR signaling pathway, emphasizing its critical role in LPS\/D\u2010GalN\u2010induced ALF treatment.<\/jats:p>","DOI":"10.1002\/jbt.23577","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T11:33:19Z","timestamp":1699356799000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Silencing of GDF11 suppresses hepatocyte apoptosis to relieve LPS\/D\u2010GalN acute liver failure"],"prefix":"10.1002","volume":"38","author":[{"given":"Rongsheng","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaogang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3196-3224","authenticated-orcid":false,"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1673372"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2018.10.032"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-021-05289-0"},{"key":"e_1_2_10_5_1","first-page":"5887","volume":"15","author":"Wu X.","year":"2023","journal-title":"Aging"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20258"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318812"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800195R"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20190441"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2022.12.017"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13122502"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-209352"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.06.036"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.05.037"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-021-00762-2"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13532"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15493"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1543-z"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/387083a0"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01039"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.03.003"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03120-6"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2021.194782"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312886"},{"key":"e_1_2_10_25_1","first-page":"6908","volume":"24","author":"Xu H. 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