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The protective effect of tyrosol (Tyr) pretreatment against DCF\u2010induced renal damage was investigated in this study. The 32 rats used in the study were randomly divided into four groups of eight rats each. According to the data obtained, it was determined that creatinine, urea, and blood urea nitrogen (BUN) levels increased in serum samples of the DCF group. Besides, the levels of reduced glutathione (GSH) and glutathione peroxidase (GPx) activity decreased and\u00a0the malondialdehyde (MDA) level increased in the kidney tissue. However, no change was observed in catalase (CAT) activity. Cyclooxygenase\u20102 (COX\u20102), nuclear factor kappa B (NF\u2010\u03baB), and tumor necrosis factor\u2010alpha (Tnf\u2010\u03b1) levels increased\u00a0and nuclear factor erythroid 2\u2010related factor 2 (Nrf\u20102) levels decreased. No change was detected in the level of interleukin 1 beta (IL\u20101\u03b2). When the\u00a0DCF+Tyr group and the\u00a0DCF group were compared, it was assessed that Tyr had a curative effect on all biochemical parameters. Also, kidney damages, such as degeneration and necrosis of tubular epithelium and congestion of veins, were obviated by treatment with tyrosol in histopathological examinations. It was determined that Tyr pretreatment provided a protective effect against nephrotoxicity induced by DCF with its anti\u2010inflammatory and antioxidant properties.<\/jats:p>","DOI":"10.1002\/jbt.23582","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T22:40:03Z","timestamp":1700260803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The effect of tyrosol on diclofenac sodium\u2010induced acute nephrotoxicity in rats"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-5148","authenticated-orcid":false,"given":"Mehmet","family":"\u00c7\u00f6mez","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Faculty of Medicine Hatay Mustafa Kemal University  Hatay Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2559-096X","authenticated-orcid":false,"given":"Mustafa","family":"Cellat","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine Hatay Mustafa Kemal University  Hatay Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1375-7673","authenticated-orcid":false,"given":"M\u00fcsl\u00fcm","family":"Kuzu","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Karabuk University Karabuk Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9694-8629","authenticated-orcid":false,"given":"Ahmet","family":"Uyar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine Hatay Mustafa Kemal University  Hatay Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1735-1774","authenticated-orcid":false,"given":"Erdin\u00e7","family":"T\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Pharmocology and Toxicology, Faculty of Veterinary Medicine Hatay Mustafa Kemal University  Hatay Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf Selim","family":"Kaya","sequence":"additional","affiliation":[{"name":"Ministry of Health Elazig Fethi Sekin City Hospital, Department of Urology Elaz\u0131\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0497-1878","authenticated-orcid":false,"given":"Muhammed","family":"Etyemez","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine University of Burdur Mehmet Akif Ersoy Burdur Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0590-6405","authenticated-orcid":false,"given":"\u0130shak","family":"G\u00f6k\u00e7ek","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine Hatay Mustafa Kemal University  Hatay Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9716-0697","authenticated-orcid":false,"given":"Mehmet","family":"G\u00fcven\u00e7","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine Hatay Mustafa Kemal University  Hatay Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-9482-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21951"},{"key":"e_1_2_10_4_1","volume":"20","author":"Franceschi F.","year":"2016","journal-title":"Eur. 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