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Matrine is an alkaloid with the effects of anti\u2010inflammation, antifibrosis and antitumour. But, few studies have explored the role of matrine in regulating PVR, and the related mechanisms are still unknown. In this study, we found that hypoxia\u2010induced pulmonary artery smooth muscle cells\u00a0(PASMCs) proliferation and inhibited its apoptosis, reduced the expression of ribosomal protein s5 and activated the nuclear factor kappa\u2010B (NF\u2010\u03baB) signalling. Matrine, sildenafil and NF\u2010\u03baB inhibitor Bay 11\u20107082 could reverse these changes and impel the cell cycle in phase S retardation, and reduced the expression of p50, p65, proliferating cell nuclear antigen (PCNA), Bcl\u20102. In addition, matrine could lower right ventricular systolic pressure and mean pulmonary artery pressure\u00a0of rats,\u00a0\u03b1\u2010smooth muscle actin\u00a0and PCNA expression in pulmonary artery media, the levels of tumor necrosis factor\u2010\u03b1 and interleuki\u20101\u03b2, thus improved hypoxia\u2010induced PVR. This study indicated that matrine could alleviate inflammation and improve PVR through reversing the imbalance of proliferation and apoptosis of PASMCs, thus it had a therapeutic effect on HPAH.<\/jats:p>","DOI":"10.1002\/jbt.23583","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T09:17:32Z","timestamp":1700558252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Matrine alleviates hypoxia\u2010induced inflammation and pulmonary vascular remodelling via RPS5\/NF\u2010\u03baB signalling pathway"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9730-1357","authenticated-orcid":false,"given":"Mingxing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacy, School of Medicine, Sir Run Run Shaw Hospital Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaofa","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine, Sir Run Run Shaw Hospital Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine, Sir Run Run Shaw Hospital Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine, Sir Run Run Shaw Hospital Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine, Sir Run Run Shaw Hospital Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-020-00375-w"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202012-4317SO"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106099"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030638"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.768513"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.753727"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2016.11.005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11726"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2021.08.023"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-63046-1_19"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9112338"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.301141"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-63046-1_15"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2019.05.002"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.16810"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4813"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026616666160506131012"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113682"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.01.013"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.11.007"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173438"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5577634"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00138"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201402-0322OC"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.394"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00022"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-020-0473-8"},{"issue":"3","key":"e_1_2_10_29_1","first-page":"1578","volume":"14","author":"Fang X.","year":"2022","journal-title":"Am. 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