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Therefore, this study aimed to clarify ovulatory dysfunction (OD) associated with LTG and the role of curcumin in ameliorating this dysfunction. Adult female Wister albino rats were assigned into four groups: negative control (received saline), positive control (received curcumin only), LTG, and LTG with curcumin groups. Drugs were administered for 90 days. The hormonal profile, including testosterone, estrogen, progesterone, luteinizing hormone, and follicle\u2010stimulating hormone, in addition to the lipid profile and glycemic analysis, were tested. Oxidative stress biomarkers analysis in the ovaries and uterus and peroxisome proliferator\u2010activated receptor\u2010\u03b3 (PPAR\u2010\u03b3) gene expression were also included. Histopathological examination of ovarian and uterine tissues and immunohistochemical studies were also performed. Curcumin could improve the OD related to chronic LTG intake. That was proved by the normalization of the hormonal profile, glycemic control, lipidemic status, oxidative stress markers, and PPAR\u2010\u03b3 gene expression. The histopathological and immunohistochemical examination of ovarian and uterine tissues revealed an improvement after curcumin administration. The results describe an obvious deterioration in ovarian performance with LTG through the effect on lipidemic status, PPAR\u2010\u03b3 gene, and creating an oxidative stress condition in the ovaries of chronic users, with a prominent improvement with curcumin addition to the treatment protocol.<\/jats:p>","DOI":"10.1002\/jbt.23599","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T02:54:35Z","timestamp":1701744875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Curcumin protects against lamotrigine\u2010induced chronic ovarian and uterine toxicity in rats by regulating PPAR\u2010\u03b3 and ROS production"],"prefix":"10.1002","volume":"38","author":[{"given":"Meriam N. 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