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COVID\u201019 is primarily asymptomatic though it may cause acute lung injury (ALI), acute respiratory distress syndrome (ARDS), systemic inflammation, and thrombotic events in severe cases. SARS\u2010CoV\u20102\u2010induced OS triggers the activation of different signaling pathways, which counterbalances this complication. One of these pathways is nuclear factor erythroid 2\u2010related factor 2 (Nrf2), which induces a series of cellular interactions to mitigate SARS\u2010CoV\u20102\u2010mediated viral toxicity and OS\u2010induced cellular injury. Nrf2 pathway inhibits the expression of pro\u2010inflammatory cytokines and the development of cytokine storm in COVID\u201019. Therefore, Nrf2 activators may play an essential role in reducing SARS\u2010CoV\u20102 infection\u2010induced inflammation by suppressing NLRP3 inflammasome in COVID\u201019. 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