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A rat model of THS was induced by hemorrhage from a left femur fracture, while an oxygen\u2010glucose deprivation\/reoxygenation (OGD\/R)\u2010induced HULEC\u20105a\u00a0cell model was considered as an in vitro THS\u00a0model. The lung tissue pathology and glycocalyx structure were assessed through hematoxylin\u2013eosin (H&amp;E) staining and transmission electron microscope examination. The levels of glycocalyx\u2010related factors and inflammation\u2010related factors were determined by enzyme\u2010linked immunosorbent assay (ELISA).\u00a0The expression of glycocalyx\u2010related proteins, cell junction\u2010related proteins, and proteins involved in the PI3K\/Akt\/NF\u2010\u03baB signaling pathway was analyzed by western blot. The results showed that both sodium bicarbonate Ringer's solution (BRS)\u00a0and lactate Ringer's solution (LRS)\u00a0were effective in restoring mean arterial pressure and heart rate in THS rats. However, LRS has a stronger impact on promoting inflammation and damaging the glycocalyx compared with\u00a0BRS. In OGD\/R\u2010induced HULEC\u20105a cells, a pH of 7.4 and 6.5 increased inflammation and disrupted the glycocalyx, while a pH of 8.1 had no significant effect on inflammation or glycocalyx. Furthermore, the PI3K\/Akt\/NF\u2010\u03baB\u00a0signaling pathway was activated by fluid resuscitation and different pH values. However, the activating effect of BRS and pH 8.1 on the PI3K\/Akt\/NF\u2010\u03baB\u00a0signaling pathway was milder compared with\u00a0LRS and pH6.5. In conclusion, an alkaline recovery environment was more beneficial for the treatment of THS.<\/jats:p>","DOI":"10.1002\/jbt.23608","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T17:14:12Z","timestamp":1702401252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of sodium bicarbonate Ringer's solution on lung injury in rats with traumatic hemorrhagic shock"],"prefix":"10.1002","volume":"38","author":[{"given":"Zhenjie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine The First Affiliated Hospital of Bengbu Medical College Bengbu Anhui China"},{"name":"Institute of Emergency and Critical Care Medicine The First Affiliated Hospital of Bengbu Medical College Bengbu Anhui 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