{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:24:48Z","timestamp":1774869888367,"version":"3.50.1"},"reference-count":80,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nanotechnology and its application to manipulate herbal compounds to design new neuroprotective agents to manage neurotoxicity has recently increased. Cur\u2010ZnO conjugated nanoparticles were synthesized and used in an experimental model of ketamine\u2013induced neurotoxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cur\u2010ZnO conjugated nanoparticles were chemically characterized, and the average crystalline size was determined. Forty\u2010nine adult mice were divided into seven groups of seven animals each. Normal saline was given to control mice (group 1). Ketamine (25\u2009mg\/kg) was given to a second group. A third group of mice was given ketamine (25\u2009mg\/kg) in combination with curcumin (40\u2009mg\/kg), while mice in groups 4, 5, and 6 received ketamine (25\u2009mg\/kg) plus Cur\u2010ZnO nanoparticles (10, 20, and 40\u2009mg\/kg). Group 7 received only ZnO (5\u2009mg\/kg). All doses were ip for 14 days. Hippocampal mitochondrial quadruple complex enzymes, oxidative stress, inflammation, and apoptotic characteristics were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cur\u2010ZnO nanoparticles and curcumin decreased lipid peroxidation, GSSG content, IL\u20101\u03b2, TNF\u2010\u03b1, and Bax levels while increasing GSH and antioxidant enzymes like GPx, GR, and SOD while increasing Bcl\u20102 level and mitochondrial quadruple complex enzymes in ketamine treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The neuroprotective properties of Cur\u2010ZnO nanoparticles were efficient in preventing ketamine\u2010induced neurotoxicity in the mouse brain. The nanoparticle form of curcumin (Cur\u2010ZnO) required lower doses to produce neuroprotective effects against ketamine\u2010induced toxicity than conventional curcumin.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jbt.23611","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T17:21:59Z","timestamp":1702401719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Curcumin\u2010ZnO conjugated nanoparticles confer neuroprotection against ketamine\u2010induced neurotoxicity"],"prefix":"10.1002","volume":"38","author":[{"given":"Fatemeh","family":"Mobinhosseini","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa","family":"Salehirad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wallace Hayes","sequence":"additional","affiliation":[{"name":"College of Public Health University of South Florida Tampa Florida USA"},{"name":"Institute for Integrative Toxicology Michigan State University East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3449-4224","authenticated-orcid":false,"given":"Majid","family":"Motaghinejad","sequence":"additional","affiliation":[{"name":"Chronic Respiratory Disease Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malak","family":"Hekmati","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sepideh","family":"Safari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Gholami","sequence":"additional","affiliation":[{"name":"College of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015911795017155"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10349"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22536"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0897190014525754"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/joacp.JOACP_415_19"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm084"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.09.035"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4666-x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.06.041"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02295-9"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.02.051"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2015.56355"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.07.059"},{"issue":"1","key":"e_1_2_12_15_1","first-page":"1","volume":"9","author":"Kandezi N.","year":"2020","journal-title":"Int. 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