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Diabetes mellitus (DM) is a chronic metabolic disease characterized by high blood sugar, polyuria, polydipsia, and polyphagia, in which insulin secreted from pancreatic \u03b2 cells is inadequate for maintaining blood glucose homeostasis. Rats were application 65\u2009mg\/kg streptozotocin (STZ) solution intraperitoneally and a diabetes model was created. For this purpose, freshly prepared STZ was injected into the peritoneum. Tumor necrosis factor\u2010\u03b1, interleukin\u00a0(IL)\u201010, IL\u20106, and IL\u20101\u03b2 levels in STZ, MSG, and STZ\u2009+\u2009MSG groups were found to be significantly increased in inflammation parameters measured on the 28th day of administration when compared to the Control Group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Also, although malondialdehyde\u00a0(MDA) levels increased significantly in the STZ\u2009+\u2009MSG group when compared to the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), glutathione\u00a0(GSH), and superoxide dismutase\u00a0(SOD) levels were significantly decreased in the STZ, MSG, and STZ\u2009+\u2009MSG groups when compared to the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Also, although glucose levels increased significantly in STZ and STZ\u2009+\u2009MSG at the end of the 28th day (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), insulin levels decreased in STZ, MSG, and STZ\u2009+\u2009MSG groups when compared to the control groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). As a result, it was found that STZ and MSG application significantly increased cytokine production, increased MDA, which is an oxidant parameter in pancreatic tissue, and decreased antioxidants (GSH and SOD) when compared to the control groups. It was also found that MSG disrupted the normal histological structure in pancreatic cells, and the damage was much more in both exocrine and endocrine pancreatic areas in the STZ\u2009+\u2009MSG group when compared to the STZ and MSG groups. It was considered that with the increased use of MSG, the susceptibility to DM might increase along with tissue damage significantly in diabetic groups, therefore, MSG must be used in a limited and controlled manner.<\/jats:p>","DOI":"10.1002\/jbt.23612","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T17:21:27Z","timestamp":1702401687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The investigation of the effects of monosodium glutamate on healthy rats and rats with STZ\u2010induced diabetes"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1852-3614","authenticated-orcid":false,"given":"Sevda","family":"Urcar Gelen","sequence":"first","affiliation":[{"name":"Department of Food Hygiene and Technology, Faculty of Veterinary Medicine Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seckin","family":"Ozkanlar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semin","family":"Gedikli","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Veterinary Medicine Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Atasever","sequence":"additional","affiliation":[{"name":"Department of Food Hygiene and Technology, Faculty of Veterinary Medicine Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/27.9.847"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-020-05056-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/189402"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5604\/00306657.1199991"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/JN\/130.4.921S"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0172534"},{"issue":"7","key":"e_1_2_9_8_1","volume":"15","author":"Mortensen A.","year":"2017","journal-title":"EFSA J."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/125.11.2891S"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-9-50"},{"key":"e_1_2_9_11_1","first-page":"34","volume":"11","author":"Eweka A. 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