{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:13:42Z","timestamp":1781828022892,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Renal interstitial fibrosis (RIF) represents an irreversible and progressive pathological manifestation of chronic renal disease, which ultimately leads to end\u2010stage renal disease. Long noncoding RNAs (lncRNAs) have been suggested to be involved in the progression of RIF. Small nucleolar RNA host gene 16 (SNHG16), a member of lncRNAs, has been found to be involved in the progression of pulmonary fibrosis. This paper first researched the effect of SNHG16 on renal fibrosis. We established a unilateral ureteral obstruction (UUO)\u2010induced mouse RIF model by ligation of the left ureter to evaluate the biological function of SNHG16 in RIF. As a result, SNHG16 was upregulated in UUO\u2010induced renal fibrotic tissues. Knockdown of SNHG16 inhibited RIF and reduced alpha\u2010smooth muscle actin\u00a0(\u03b1\u2010SMA), fibronectin, and college IV expression. miR\u2010205 was a target of SNHG16, and downregulated in UUO\u2010induced renal fibrotic tissues. Inhibition of miR\u2010205 promoted RIF and increased the expression of \u03b1\u2010SMA, college IV, and fibronectin. Overexpression of SNHG16 promoted the UUO\u2010induced RIF, but miR\u2010205 abrogated this effect of SNHG16. Histone deacetylase 5 (HDAC5) showed high expression in UUO\u2010induced renal fibrotic tissues. Knockdown of HDAC5 significantly reduced \u03b1\u2010SMA, fibronectin, and college IV expression in renal tissues of UUO\u2010induced mice. Inhibition of miR\u2010205 promoted HDAC5 expression, but knockdown of SNHG16 inhibited HDAC5 expression in renal tissues of UUO\u2010induced mice. In conclusion, SHNG16 is highly expressed in renal fibrotic tissues of UUO\u2010induced mice. Knockdown of SHNG16 may prevent UUO\u2010induced RIF by indirectly upregulating HDAC5 via targeting miR\u2010205. SHNG16 may be novel target for treating renal fibrosis.<\/jats:p>","DOI":"10.1002\/jbt.23617","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T21:35:03Z","timestamp":1702330503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["SNHG16\/miR\u2010205\/HDAC5 is involved in the progression of renal fibrosis"],"prefix":"10.1002","volume":"38","author":[{"given":"Yingdan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Nephrology, Jiading Branch of Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Jing\u2018an District Center Hospital of Shanghai, Fudan University  Shanghai City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhai","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Jiading Branch of Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Jiading Branch of Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Jiading Branch of Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Jiading Branch of Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Jiading Branch of Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8531-134X","authenticated-orcid":false,"given":"Zhihuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Jiading Branch of Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai City China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034227"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.37349\/emed.2020.00004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60696-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.54"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11019"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.621"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00382.2021"},{"issue":"9","key":"e_1_2_10_9_1","first-page":"1365","volume":"54","author":"Zhang Y.","year":"2022","journal-title":"Acta Biochim. 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