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This study aimed to investigate the correlation between the molecular mechanisms of nicotine\u2010induced liver injury, the caspase cascade, and the Akt\/NF\u2010\u03baB signaling pathway, as well as the protective effects of dexpanthenol (DEX). Male rats were subjected to intraperitoneal injections of nicotine at a concentration of 0.5\u2009mg\/kg\/day and\/or DEX at a concentration of 500\u2009mg\/kg\/day for 8 weeks. After the treatment period, liver function tests were conducted on serum samples, and tissue samples were analyzed for protein levels of Akt, NF\u2010\u03baB, Bax, Bcl\u2010xL, Caspase\u20103, and Caspase\u20109, along with histopathological changes. Additionally, assessments of oxidative stress markers and proinflammatory cytokines were carried out. Nicotine administration led to elevated levels of IL\u20106, IL\u20101\u03b2, MDA, TOS, and oxidative stress index, accompanied by decreased TAS levels. Moreover, nicotine exposure reduced the p\u2010Akt\/Akt ratio, increased NF\u2010\u03baB, Bax, Caspase\u20103, and Caspase\u20109 protein levels, and decreased the antiapoptotic protein Bcl\u2010xL levels. DEX treatment significantly mitigated these effects, restoring the parameters to levels comparable to those of the control group. Nicotine\u2010induced liver injury resulted in oxidative stress, inflammation, and apoptosis, mediated by Bax\/Bcl\u2010xL, Caspase\u20103, Caspase\u20109, and Akt\/NF\u2010\u03baB pathways. Conversely, DEX effectively attenuated nicotine\u2010induced liver injury by modulating apoptosis through NF\u2010\u03baB, Caspase\u20103, Caspase\u20109, Bax inhibition, and Bcl\u2010xL activation.<\/jats:p>","DOI":"10.1002\/jbt.23622","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T01:53:59Z","timestamp":1704246839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Dexpanthenol exhibits antiapoptotic and anti\u2010inflammatory effects against nicotine\u2010induced liver damage by modulating Bax\/Bcl\u2010xL, Caspase\u20103\/9, and Akt\/NF\u2010\u03baB pathways"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-4352","authenticated-orcid":false,"given":"Nuray","family":"\u00dcremi\u015f","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Medical Faculty Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meral","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Medical Faculty Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Ta\u015flidere","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical Faculty Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"G\u00fcrel","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Medical Faculty Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00464-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2021.07.016"},{"issue":"1","key":"e_1_2_10_4_1","first-page":"33","volume":"59","author":"Sobkowiak R.","year":"2013","journal-title":"Postepy Biochem."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2004.04.012"},{"key":"e_1_2_10_6_1","first-page":"514","author":"Holloway A. 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