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PDAC is the most\u00a0encountered pancreatic cancer type. One of the most important characteristic features of PDAC is neuropathy which is primarily due to perineural invasion (PNI). PNI develops tumor microenvironment which includes overexpression of fibroblasts cells, macrophages, as well as angiogenesis which can be responsible for neuropathy pain. In tumor microenvironment inactive fibroblasts are converted into an active form that is cancer\u2010associated fibroblasts (CAFs). Neurotrophins they also increase the level of Substance P, calcitonin gene\u2010related peptide which is also involved in pain. Matrix metalloproteases are the zinc\u2010associated proteases enzymes which activates proinflammatory interleukin\u20101\u03b2 into its activated form and are responsible for release and activation of Substance P which is responsible for neuropathic pain by transmitting pain signal via dorsal root ganglion. All the molecules and their role in being responsible for neuropathic pain are described below.<\/jats:p>","DOI":"10.1002\/jbt.23638","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T08:19:17Z","timestamp":1712996357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Molecular pathway of pancreatic cancer\u2010associated neuropathic pain"],"prefix":"10.1002","volume":"38","author":[{"given":"Shweta Subhash","family":"Giri","sequence":"first","affiliation":[{"name":"Amity Institute of Pharmacy Amity University Noida Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9931-5488","authenticated-orcid":false,"given":"Alok Shiomurti","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Era College of Pharmacy Era University Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u0131nar","family":"Erkeko\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy Hacettepe University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdi E. 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