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Naringin (NRG), a natural flavonoid, has come to the fore as its antioxidant, anti\u2010inflammatory, and antiapoptotic activities. The aim of the present study was to determine whether NRG has protective effects on COL\u2010induced toxicity in testicular tissue. Thirty\u2010five male Spraque rats were randomly divided into five groups (<jats:italic>n<\/jats:italic>\u2009=\u20097 per group): Control, COL, NRG, COL\u2009+\u2009NRG 50, COL\u2009+\u2009NRG 100. COL (15\u2009mg\/kg b.w., i.p., once per\/day), and NRG (50\u00a0or 100\u2009mg\/kg, oral, b.w.\/once per\/day) were administered for 7 days. The parameters of oxidative stress, inflammation, apoptosis, and autophagic damage were evaluated by using biochemical, molecular, western blot, and histological methods in testicular issues. NRG treatment reversed the increased malondialdehyde level and reduced antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione) levels due to COL administration (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and oxidative stress damage was mitigated. Nuclear factor erythroid 2\u2010related factor\u20102 pathway, one of the antioxidant defence systems, was stimulated by NRG (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). NRG treatment reduced the levels of markers for the pathways of apoptotic (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and autophagic (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) damages induced by COL. Sperm viability and the live\/dead ratio were reduced by COL but enhanced by NRG treatment. Testicular tissue integrity was damaged by COL but showed a tendency to improve by NRG. In conclusion, COL exhibited toxic effect on testicular tissue by elevating the levels of oxidative stress, apoptosis, autophagy, inflammation, and tissue damage. NRG demonstrated a protective effect by alleviating toxic damage.<\/jats:p>","DOI":"10.1002\/jbt.23643","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T06:59:56Z","timestamp":1705906796000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Protective effects of naringin on colistin\u2010induced damage in rat testicular tissue: Modulating the levels of Nrf\u20102\/HO\u20101, AKT\u20102\/FOXO1A, Bax\/Bcl2\/Caspase\u20103, and Beclin\u20101\/LC3A\/LC3B signaling pathways"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3747-3798","authenticated-orcid":false,"given":"Naz\u0131m Abd\u00fclkadir","family":"Kank\u0131l\u0131\u00e7","sequence":"first","affiliation":[{"name":"Department of Urology, Faculty of Medicine Aksaray University  Aksaray 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