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The aim of this study is to reveal the cardioprotective effects of 18\u03b2\u2010glycyrretinic acid (GA) against BPA\u2010induced cardiotoxicity in rats. In this study, 40 male rats were used and five different groups (each group includes eight rats) were formed. The rats were applied BPA (250\u2009mg\/kg b.w.) alone or with GA (50 and 100\u2009mg\/kg b.w.) for 14 days. Rats were killed on Day 15 and heart tissues were taken for analysis. GA treatment decreased serum lactate dehydrogenase and\u00a0creatine kinase MB levels, reducing BPA\u2010induced heart damage. GA treatment showed ameliorative effects against lipid peroxidation and oxidative stress caused by BPA by increasing the antioxidant enzyme activities (glutathione peroxidase, superoxide dismutase, and catalase) and GSH level of the heart tissue and decreasing the MDA level. In addition, GA showed antiapoptotic effect by increasing Bcl\u20102, procaspase\u20103, and \u20109 protein expression levels and decreasing Bax, cytochrome c, and P53 protein levels in heart tissue. As a result, it was found that GA has cardioprotective effects on heart tissue by exhibiting antioxidant and antiapoptotic effects against heart damage caused by BPA, an environmental pollutant. Thus, it was supported that GA could be a potential cardioprotective agent.<\/jats:p>","DOI":"10.1002\/jbt.23655","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T11:29:46Z","timestamp":1706095786000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["18\u03b2\u2010Glycyrrhetinic acid exerts cardioprotective effects against BPA\u2010induced cardiotoxicity through antiapoptotic and antioxidant mechanisms"],"prefix":"10.1002","volume":"38","author":[{"given":"Ibrahim","family":"Bayav","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine Pamukkale University Denizli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekrem","family":"Darendelio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science and Literature Bingol University Bingol Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-554X","authenticated-orcid":false,"given":"Cuneyt","family":"Caglayan","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Bilecik Seyh Edebali University Bilecik Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.139190"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2011.04.010"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2019.03.006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-022-09719-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.131151"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kft026"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22687"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.11.1303"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008673"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2013.08.008"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP378"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10081105"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa139"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2022.04.002"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082661"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1806927"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02689-3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10020282"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22030"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-022-01027-z"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.105714"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.037705"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22920"},{"key":"e_1_2_10_25_1","volume":"58","author":"T\u00fcrkmen N. 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