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Human umbilical cord\u2010derived mesenchymal stem cells (Hu\u2010MSCs) can migrate to tumor sites and exert complex functions throughout tumor progression. In this study, we successfully isolated Hu\u2010MSCs from human umbilical cords based on their surface marker expression. Hu\u2010MSC\u2010derived exosomes significantly reduced the invasion, migration, and proliferation of cholangiocarcinoma (CCA) cells. Furthermore, circ_0037104 was downregulated in CCA\u00a0and inhibited the proliferation and metastasis of CCA\u00a0cells. Then, we investigated the effect of Hu\u2010MSC\u2010derived exosomal circ_0037104 on CCA. Circ_0037104 mainly regulates miR\u2010620 and enhances APAF1 expression, inhibiting CCA cell proliferation and metastasis. Overall, Hu\u2010MSC exosomal circ_0037104 contributes to the progression and stemness of CCA\u00a0cells via miR\u2010620\/APAF1. In conclusion, Hu\u2010MSC\u2010derived exosomal circ_0037104 sponges miR\u2010620 directly and negatively targets APAF1 to suppress CCA.<\/jats:p>","DOI":"10.1002\/jbt.23656","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T15:04:29Z","timestamp":1706367869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exosomal circ_0037104 derived from Hu\u2010MSCs inhibits cholangiocarcinoma progression by sponging miR\u2010620 and targeting AFAP1"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7927-1844","authenticated-orcid":false,"given":"Zilin","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Center General Hospital of Central Theatre Command of People's Liberation Arm Wuhan Hubei 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