{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:54:45Z","timestamp":1783461285504,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiovascular diseases cause a large number of deaths throughout the world. No research was conducted earlier on p\u2010coumaric acid's effect on tachycardia, inflammation, ion pump dysfunction, and electrolyte imbalance. Hence, we appraised the above\u2010said parameters in isoproterenol\u2010induced myocardial infarcted rats. This investigation included 24 male albino Wistar rats in 4 groups. Normal control Group 1, p\u2010coumaric acid (8\u2009mg\/kg body weight) alone treated Group 2, Isoproterenol (100\u2009mg\/kg body weight) induced myocardial infarcted Group 3, p\u2010coumaric acid (8\u2009mg\/kg body weight) pretreated isoproterenol (100\u2009mg\/kg body weight) induced Group 4. After 1 day of the last dose of isoproterenol injection (day 10), rats were killed and blood and heart were taken and inflammatory markers, lipid peroxidation, nonenzymatic antioxidants, ion pumps, and electrolytes were measured. The heart rate, serum cardiac troponin\u2010T, serum\/plasma inflammatory markers, and heart proinflammatory cytokines were raised in isoproterenol\u2010induced rats. Isoproterenol also enhanced plasma lipid peroxidation, lessened plasma nonenzymatic antioxidants, and altered heart ion pumps and serum and heart electrolytes. In this study, p\u2010coumaric acid pretreatment orally for 7 days to isoproterenol\u2010induced myocardial infarcted rats prevented changes in the above\u2010cited parameters. p\u2010Coumaric acid's anti\u2010tachycardial, anti\u2010inflammatory, anti\u2010ion pump dysfunction and anti\u2010electrolyte imbalance properties are the mechanisms for these cardioprotective effects.<\/jats:p>","DOI":"10.1002\/jbt.23668","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T07:39:51Z","timestamp":1709624391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cardioprotective effects of p\u2010coumaric acid on tachycardia, inflammation, ion pump dysfunction, and electrolyte imbalance in isoproterenol\u2010induced experimental myocardial infarction"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6840-4074","authenticated-orcid":false,"given":"Stanely Mainzen Prince","family":"Ponnian","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Medicinal and Biomolecular Chemistry Laboratory Annamalai University Annamalai Nagar Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shervin Prince","family":"Stanely","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Karunya Institute of Technology and Sciences  Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhro Jyoti","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Medicinal and Biomolecular Chemistry Laboratory Annamalai University Annamalai Nagar Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"443","volume":"67","author":"Rona G.","year":"1959","journal-title":"A.M.A. Archives Pathol."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21668"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2019.09.015"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.07.049"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.174975"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.11.012"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.04.052"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.04.138"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22907"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-3084(87)90071-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"e_1_2_9_13_1","first-page":"3","volume-title":"Methods of Enzymology","author":"Omaye S. T.","year":"1979"},{"key":"e_1_2_9_14_1","first-page":"531","volume":"21","author":"Baker H.","year":"1980","journal-title":"Nutr. Rep. Int."},{"key":"e_1_2_9_15_1","first-page":"257","volume-title":"Membranes and ion transport","author":"Bonting S. L.","year":"1970"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(83)90480-7"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)84756-1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.174909"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.37896\/YMER21.04\/05"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.055"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.18203\/2349-3933.ijam20183119"},{"key":"e_1_2_9_23_1","first-page":"94","volume":"11","author":"Sudheer A.","year":"2021","journal-title":"J. Appl. Pharmaceut. Sci."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.21608\/ejhm.2022.260746"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.23668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T07:24:35Z","timestamp":1710401075000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.23668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/jbt.23668"],"URL":"https:\/\/doi.org\/10.1002\/jbt.23668","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23668"}}