{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:07:13Z","timestamp":1785186433734,"version":"3.55.0"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671316"],"award-info":[{"award-number":["81671316"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Accumulating evidence confirms that sleep insufficiency is a high risk factor for cognitive impairment, which involves inflammation and synaptic dysfunction. Resveratrol, an agonist of the Sirt1, has demonstrated anti\u2010inflammation and neuroprotective effects in models of Alzheimer's disease, Parkinson's disease, and schizophrenia. However, the beneficial effects of resveratrol on sleep deprivation\u2010induced cognitive deficits and its underlying molecular mechanisms are unclear. In the present study, thirty\u2010two male C57BL\/6\u2009J mice were randomly divided into a Control+DMSO group, Control+Resveratrol group, SD+DMSO group, and SD+Resveratrol group. The mice in the SD+Resveratrol group underwent 5 days of sleep deprivation after pretreatment with resveratrol (50\u2009mg\/kg) for 2 weeks, while the mice in the SD+DMSO group only underwent sleep deprivation. After sleep deprivation, we evaluated spatial learning and memory function using the Morris water maze test. We used general molecular biology techniques to detect changes in levels of pro\u2010inflammatory cytokines and Sirt1\/miR\u2010134 pathway\u2010related synaptic plasticity proteins. We found that resveratrol significantly reversed sleep deprivation\u2010induced learning and memory impairment, elevated interleukin\u20101\u03b2, interleukin\u20106, and tumor necrosis factor\u2010\u03b1 levels, and decreased brain\u2010derived neurotrophic factor, tyrosine kinase receptor B, postsynaptic density protein\u201095, and synaptophysin levels by activating the Sirt1\/miR\u2010134 pathway. In conclusion, resveratrol is a promising agent for preventing sleep deprivation\u2010induced cognitive dysfunction by reducing pro\u2010inflammatory cytokines and improving synaptic function via the Sirt1\/miR\u2010134 pathway.<\/jats:p>","DOI":"10.1002\/jbt.23698","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T12:48:25Z","timestamp":1710852505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Resveratrol prevents cognitive deficits induced by sleep deprivation via modulating sirtuin 1 associated pathways in the hippocampus"],"prefix":"10.1002","volume":"38","author":[{"given":"Yue\u2010Ming","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology (Sleep Disorders) the Affiliated Chaohu Hospital of Anhui Medical University Hefei 238000 Anhui PR 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