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The expression of numerous circular ribonucleic acids (circRNAs) is disrupted in I\/R\u2010induced cardiac damage, but the potential role of circRNAs in I\/R damage has not been fully elucidated. The purpose of the present study was to clarify the biological action and molecular mechanism of circRNA 002166 (also termed circCL2L13) in postmyocardial I\/R. Oxygen\u2013glucose deprivation\/reoxygenation (OGD\/R) in an in vivo model was performed to simulate I\/R damage. real\u2010time polymerase chain reaction analysis was also conducted to evaluate the relationships of the SOD1, SOD2, NRF2, HO1 and GPX4 indicators with oxidative stress injury. TUNEL immunofluorescence was used to evaluate the degree of cardiomyocyte apoptosis in the different treatment groups. The circBCL2L13 level was markedly upregulated in myocardial tissues from a mouse I\/R model. Overexpression of circBCL2L13 markedly attenuated the expression of oxidative stress\u2010related genes and apoptosis in OGD\/R\u2010induced cardiomyocytes. A mechanistic study revealed that circBCL2L13 functions as a ceRNA for miR\u20101246 and modulates paternally expressed gene 3 (PEG3). Eventually, circBCL2L13 was proven to regulate PEG3 by targeting miR\u20101246, thereby protecting against OGD\/R\u2010induced cardiomyocyte oxidative damage and apoptosis. In conclusion, our study confirmed that the circBCL2L13\/miR\u20101246\/PEG3 axis suppressed the progression of OGD\/R injury in cardiomyocytes, which might lead to new therapeutic strategies for cardiac I\/R injury.<\/jats:p>","DOI":"10.1002\/jbt.23711","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T04:14:11Z","timestamp":1712895251000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["CircBCL2L13 attenuates cardiomyocyte oxidative stress and apoptosis in cardiac ischemia\u2012reperfusion injury via miR\u20101246\/PEG3 signaling"],"prefix":"10.1002","volume":"38","author":[{"given":"Hua","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Radiology First People's Hospital of Jingdezhen Jingdezhen Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hairui","family":"Li","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine The University of Hong Kong Shen Zhen Hospital Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine The University of Hong Kong Shen Zhen Hospital Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Medicine (Section of Cardiovascular Research) Baylor College of Medicine Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongbin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze\u2010Mu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2658-3200","authenticated-orcid":false,"given":"Weipeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology South China Hospital of Shenzhen University Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.792592"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.12.026"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-020-09720-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.8009"},{"issue":"168","key":"e_1_2_9_6_1","first-page":"13","volume":"33","author":"Sun Y.","year":"2022","journal-title":"Discov. 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