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Naringenin (NAR) is a dietary flavonoid with potent antioxidant and anti\u2010inflammatory properties which was implemented against AlCl<jats:sub>3<\/jats:sub>\u2010induced neurotoxicity to ascertain its neuroprotective efficacy. Experimental neurotoxicity in mice was induced by exposure of AlCl<jats:sub>3<\/jats:sub> (10\u2009mg\/kg, p.o.) followed by treatment with NAR (10\u2009mg\/kg, p.o.) for a total of 63 days. Assessed the morphometric, learning memory dysfunction (novel object recognition, T\u2010 and Y\u2010maze tests), neuronal oxidative stress, and histopathological alteration in different regions of the brain, mainly cortex, hippocampus, thalamus, and cerebellum. AlCl<jats:sub>3<\/jats:sub> significantly suppressed the spatial learning and memory power which were notably improved by administration of NAR. The levels of oxidative stress parameters nitric oxide, advanced oxidation of protein products, protein carbonylation, lipid peroxidation, superoxide dismutase, catalase, glutathione reductase, reduced glutathione, and the activity of acetylcholine esterase were altered 1.5\u20133 folds by AlCl<jats:sub>3<\/jats:sub> significantly. Treatment of NAR remarkably restored the level of oxidative stress parameters and maintained the antioxidant defense system. AlCl<jats:sub>3<\/jats:sub> suppressed the expression of neuronal proliferation marker NeuN that was restored by NAR treatment which may be a plausible mechanism. NAR showed therapeutic efficacy as a natural supplement against aluminum\u2010intoxicated memory impairments and histopathological alteration through a mechanism involving an antioxidant defense system and neuronal proliferation.<\/jats:p>","DOI":"10.1002\/jbt.23717","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T12:50:57Z","timestamp":1715691057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Naringenin mitigates aluminum toxicity\u2010induced learning memory impairments and neurodegeneration through amelioration of oxidative stress"],"prefix":"10.1002","volume":"38","author":[{"given":"Ravina","family":"Rai","sequence":"first","affiliation":[{"name":"Department of Zoology, School of Biological Sciences Dr. Harisingh Gour Central University  Sagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-3889","authenticated-orcid":false,"given":"Deepali","family":"Jat","sequence":"additional","affiliation":[{"name":"Department of Zoology, School of Biological Sciences Dr. Harisingh Gour Central University  Sagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1627-1377","authenticated-orcid":false,"given":"Siddhartha Kumar","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Lucknow  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1480553"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.111"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.12.009"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.111270"},{"key":"e_1_2_11_6_1","first-page":"1","volume":"2011","author":"Kawahara M.","year":"2011","journal-title":"Int. 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