{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:55:04Z","timestamp":1792637704955,"version":"4.5.0"},"reference-count":87,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Paclitaxel (PTX), which is actively used in the treatment of many types of cancer, has a toxic effect by causing increased oxidative stress in testicular tissues. Naringin (NRG) is a natural flavonoid found in plants, and its antioxidant properties are at the forefront. This study aims to investigate the protective feature of NRG in PTX\u2010induced testicular toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Thirty\u2010five male Sprague rats were divided into five groups: control, NRG, PTX, PTX\u2009+\u2009NRG50, and PTX\u2009+\u2009NRG100. Rats were administered PTX (2\u2009mg\/kg, BW) intraperitoneally once daily for the first 5 days. Then, between the 6th and 14th days, NRG (50 and 100\u2009mg\/kg) was administered orally once a day.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>NRG reduced PTX\u2010induced lipid peroxidation and increased testicular tissue antioxidant capacity (superoxide dismutase, catalase, glutathione peroxidase, and glutathione). While NRG reduces the mRNA expression levels of nuclear factor kappa B, tumor necrosis factor\u2010alpha, interleukin\u20101 beta, cyclooxygenase\u20102, interleukin\u20106, inducible\u2010nitric oxide synthase, mitogen\u2010activated protein kinase 14 (MAPK)14, MAPK15, c\u2010Jun N\u2010terminal kinase, P53, Apaf1, Caspase3, Caspase6, Caspase9, and Bax in testicular tissues; it caused an increase in Nrf2, HO\u20101, NQO1 and Bcl\u20102 levels. NRG also improved the structural and functional integrity of testicular tissue disrupted by PTX. PTX\u2010induced sperm damage was alleviated by NRG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>NRG showed a protective effect by alleviating the PTX\u2010induced testicular toxicity by increasing oxidative stress, inflammation, apoptosis, and autophagy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbt.23751","type":"journal-article","created":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T05:45:03Z","timestamp":1718516703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Naringin protects against paclitaxel\u2010induced toxicity in rat testicular tissues by regulating genes in pro\u2010inflammatory cytokines, oxidative stress, apoptosis, and JNK\/MAPK signaling pathways"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3747-3798","authenticated-orcid":false,"given":"Naz\u0131m Abd\u00fclkadir","family":"Kank\u0131l\u0131\u00e7","sequence":"first","affiliation":[{"name":"Department of Urology, Faculty of Medicine Aksaray University Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sefa","family":"K\u00fc\u00e7\u00fckler","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biochemistry, Faculty of Veterinary Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6775-7858","authenticated-orcid":false,"given":"Cihan","family":"G\u00fcr","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Techniques Vocational School of Health Services Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4450-6540","authenticated-orcid":false,"given":"Serkan Ali","family":"Akarsu","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine Ataturk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurhan","family":"Akaras","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Aksaray University Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"\u015eim\u015fek","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Aksaray University Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4581-4492","authenticated-orcid":false,"given":"Mustafa","family":"\u0130lerit\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Horasan Vocational College Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih Mehmet","family":"Kandemir","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Aksaray University Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110275"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2016.12.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21971"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103095"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00368"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520620666200218110645"},{"issue":"1","key":"e_1_2_10_8_1","first-page":"44","volume":"4","author":"\u00d6zt\u00fcrk N.","year":"2024","journal-title":"Laboratuvar Hayvanlar\u0131 Bilimi ve Uygulamalar\u0131 Dergisi"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(20)60032-2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-022-01750-z"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13394"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2022.101966"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122096"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.14028"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8739815"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23406"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02689-3"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-011-0774-2"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12516"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929866526666190301115122"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202301613"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmr.3004"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-14049-4"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-020-11327-5"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119730"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/2221-1691.343390"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23604"},{"issue":"1","key":"e_1_2_10_28_1","first-page":"53","volume":"41","author":"Y\u0131lmaz S.","year":"2023","journal-title":"J. Exp. Clin. Med."},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112266"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2019.06.007"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23728"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/01913123.2022.2132337"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120104"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-020-01987-y"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(66)90167-9"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.08.016"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.3.497"},{"key":"e_1_2_10_38_1","first-page":"121","volume-title":"Catalase In Vitro. In Methods in Enzymology","author":"Aebi H.","year":"1984"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(68)90092-4"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12593"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23762"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13938"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23900"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2023.108369"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.55730\/1300-0144.5556"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23700"},{"issue":"3","key":"e_1_2_10_49_1","first-page":"364","volume":"5","author":"Akaras N.","year":"2023","journal-title":"Clin. Res."},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijfs.12637"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201100272"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2018.1470646"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/bab.2517"},{"issue":"9","key":"e_1_2_10_54_1","first-page":"1098","volume":"26","author":"\u015eim\u015fek H.","year":"2023","journal-title":"Iran. J. Basic Med. Sci."},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.13144"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1590\/acb391124"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23156"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2016.03.027"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12511"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23624"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110073"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.09.019"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2023.147502"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-023-29410-y"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111190"},{"issue":"10","key":"e_1_2_10_66_1","volume":"8","author":"Akc\u0131lar R.","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-020-03174-0"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12398"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.01.038"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2019.04.007"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-023-08286-8"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2020.10.009"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-07395-0"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2018.09.020"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23643"},{"issue":"2","key":"e_1_2_10_76_1","first-page":"96","volume":"6","author":"Simsek H.","year":"2023","journal-title":"Int. J. Med. Biochem."},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-015-1169-8"},{"issue":"2","key":"e_1_2_10_78_1","first-page":"209","volume":"19","author":"\u015eim\u015fek H.","year":"2016","journal-title":"Iran. J. Basic Med. Sci."},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118301"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202200982"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.119"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23121"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2016.1165034"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10243"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22201"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13900"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-009-0596-x"},{"issue":"3","key":"e_1_2_10_88_1","first-page":"585","volume":"10","author":"Butchi Akondi R.","year":"2011","journal-title":"Iran. J. Pharmaceut. Re."}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.23751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T06:22:44Z","timestamp":1721110964000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.23751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,16]]},"references-count":87,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/jbt.23751"],"URL":"https:\/\/doi.org\/10.1002\/jbt.23751","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,16]]},"assertion":[{"value":"2024-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23751"}}