{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:58Z","timestamp":1786978078772,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cyclophosphamide (CP) is an antineoplastic drug widely used in chemotherapy. Curcumin (CUR) and piperine (PP) show a protective effect on neurodegenerative and neurological diseases. This research was designed to measure several biochemical parameters in the brain tissue of CP\u2010applied rats to investigate the impact of combined CUR\u2013PP administration. The study evaluated six groups of eight rats: Group 1 was the control; Groups 2 and 3 were administered 200 or 300\u2009mg\/kg CUR\u2010PP via oral gavage; Group 4 received only 200\u2009mg\/kg CP on day 1; Groups 5 and 6 received CP\u2009+\u2009CUR\u2010PP for 7 days. Data from all parameters indicated that CP caused brain damage. Phosphorylated TAU (pTAU), amyloid\u2010beta peptide 1\u201342 (A\u03b21\u201342), glutamate (GLU), and gamma amino butyric acid (GABA) parameters were the same in Groups 4, 5, and 6. On the other hand, 8\u2010hydroxy\u20102\u2010deoxyguanosine (8\u2010OHdG), nitric oxide (NO), interleukin\u20106 (IL\u20106), nuclear factor kappa beta (NF\u2010k\u03b2), malondialdehyde (MDA), and tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) levels in the CP\u2009+\u2009CUR\u2010PP groups were lower than those in the CP group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). However, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and reduced glutathione (GSH) parameters were higher in the CP\u2009+\u2009CUR\u2010PP groups compared to the CP group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). It is thought that the similarity of Groups 5 and 6 with Group 4 in A\u03b21\u201342, pTAU, GLU, and GABA parameters hinder the determination of treatment protection however, they might have a therapeutic effect if the applied dose or study duration were changed. This study attempted to evaluate the effects of a CUR\u2013PP combination on CP\u2010induced brain damage in rats by measuring biochemical parameters and performing histopathological examinations. Based on the findings, this CUR\u2013PP combination could be considered an alternative medicine option in cases with conditions similar to those evaluated in this study.\n                  <\/jats:p>","DOI":"10.1002\/jbt.23760","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T07:45:20Z","timestamp":1719906320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Investigation of the effects of curcumin and piperine on cyclophosphamide\u2010induced brain injury in rats"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5675-5096","authenticated-orcid":false,"given":"Serpil","family":"Ayg\u00f6rmez","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Kafkas University Kars Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eaban","family":"Mara\u015fli","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Kafkas University Kars Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14090940"},{"key":"e_1_2_10_3_1","author":"Behairy A.","year":"2023","journal-title":"Naunyn Schmiedebergs Arch. 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