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MI was induced by isoproterenol (100\u2010mg\/kg body weight) in rats. Then, rats were treated with 3, 4\u2010dihydroxybenzoic acid (16\u2010mg\/kg body weight) for 2 weeks. Serum creatine kinase\u2010MB, cardiac troponin\u2010T, cardiac troponin\u2010I, and heart thiobarbituric acid reactive substances were significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) increased and heart superoxide dismutase and catalase activities were significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) reduced in isoproterenol\u2010induced myocardial infarcted rats. Isoproterenol induction significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) elevated the plasma homocysteine and serum high sensitivity\u2010C\u2010reactive protein levels. Furthermore, an enzyme\u2010linked immunosorbent assay, reverse transcription polymerase chain study, and immunohistochemical (IHC) staining revealed significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) elevated levels and expression of serum\/myocardial nuclear factor\u2010\u03baB, tumor necrosis factor\u2010alpha, interleukin\u20101 beta, and Interleukin\u20106 and significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) reduced levels\/expression of serum\/myocardial interleukin\u201010 in myocardial infarcted rats. Nevertheless, isoproterenol\u2010induced rats treated with 3, 4\u2010dihydroxybenzoic acid considerably (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) attenuated all the biochemical, molecular, and IHC parameters investigated and inhibited oxidative stress and inflammation and protected the heart, through its antioxidant and anti\u2010inflammatory mechanisms.<\/jats:p>","DOI":"10.1002\/jbt.23773","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T08:18:38Z","timestamp":1721377118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Protective effects of 3, 4\u2010dihydroxybenzoic acid on myocardial infarction induced by isoproterenol in rats"],"prefix":"10.1002","volume":"38","author":[{"given":"Sikha","family":"Vincent","sequence":"first","affiliation":[{"name":"Medicinal and Biomolecular Chemistry Laboratory, Department of Biochemistry and Biotechnology Annamalai University Chidambaram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shervin Prince","family":"Stanely","sequence":"additional","affiliation":[{"name":"Division of Biotechnology Karunya Institute of Technology and Sciences Coimbatore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6840-4074","authenticated-orcid":false,"given":"Stanely Mainzen Prince","family":"Ponnian","sequence":"additional","affiliation":[{"name":"Medicinal and Biomolecular Chemistry Laboratory, Department of Biochemistry and Biotechnology Annamalai University Chidambaram India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112775"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112139"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e07561"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.174975"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092090"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112900"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.174909"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2015.11.005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16620"},{"key":"e_1_2_10_11_1","unstructured":"E. 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