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The focus is on investigating VALD\u20102's protective role against cisplatin\u2010induced acute kidney injury (AKI) in mice, with a specific emphasis on mitigating oxidative stress and inflammation. The study involves daily intraperitoneal injections of amifostine or VALD\u20102 over 7 days to establish an AKI model. Subsequently, mice were assigned to normal control, cisplatin group, cisplatin + amifostine group, and cisplatin + VALD\u20102 10\u2009mg\/kg group, cisplatin + VALD\u20102 20\u2009mg\/kg, and cisplatin + VALD\u20102 40\u2009mg\/kg. Kidney injury is assessed through serum blood urea nitrogen (BUN) and creatinine (Cr) activity assays. Levels of inflammatory factors,\u00a0tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) and interleukin\u20106 (IL\u20106), in kidney tissue of mice were assessed through enzyme\u2010linked immunosorbent assay (ELISA). The protective effect of VALD\u20102 is further examined through HE staining to observe pathological changes in kidney injury. The ultrastructural changes of renal cells and tubular epithelial cells were observed by electron microscopy under experimental conditions, indicating the effect of VALD\u20102 on reversing cisplatin\u2010induced renal injury. The study delves into VALD\u20102's protective mechanisms against cisplatin\u2010induced kidney injury by using western blot analysis to assess the expression levels of superoxide dismutase (SOD), glutathione peroxidase (GSH\u2010Px), and malondialdehyde (MDA) in kidney tissues. VALD\u20102 demonstrates significant improvement in cisplatin\u2010induced AKI, as evidenced by increased BUN and Cr levels. It effectively protects kidney tissue from oxidative damage, enhancing SOD and GSH\u2010Px activities while reducing MDA levels. The study also reveals a decrease in TNF\u2010\u03b1 and IL\u20106 levels, supported by ELISA results, and histological findings confirm anti\u2010nephrotoxic effects. Western blot analysis shows an upregulation of antioxidant enzymes (SOD, GSH\u2010Px) and a reduction in MDA production. VALD\u20102 emerges as a promising mitigator of cisplatin\u2010induced AKI, showcasing its ability to enhance oxidative stress\u2010related protein expression. The findings suggest VALD\u20102 as a potential therapeutic agent for protecting against cisplatin\u2010induced kidney injury.<\/jats:p>","DOI":"10.1002\/jbt.23786","type":"journal-article","created":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T18:42:11Z","timestamp":1722105731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["VALD\u20102 mitigates cisplatin\u2010induced acute kidney injury: Mechanistic insights into oxidative stress modulation and inflammation suppression"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6849-3114","authenticated-orcid":false,"given":"Xuhui","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Oncology Gansu Provincial Hospital Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Oncology Gansu Provincial Hospital Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Oncology Gansu Provincial Hospital Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Oncology Gansu Provincial Hospital Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology Gansu Provincial Hospital Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuping","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Oncology Gansu Provincial Hospital Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology Gansu Provincial Hospital Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.1.409"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021121591"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002786"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex381"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.29261\/pakvetj\/2020.082"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-17736-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-93196-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.574441"},{"issue":"1","key":"e_1_2_9_10_1","first-page":"107","volume":"42","author":"Elsayed A.","year":"2022","journal-title":"Pak. 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