{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T20:49:44Z","timestamp":1782420584418,"version":"3.54.5"},"reference-count":287,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pulmonary injury is one of the key restricting factors for the therapy of malignancies with chemotherapy or following radiotherapy for chest cancers. The lung is a sensitive organ to some severely toxic antitumor drugs, consisting of bleomycin and alkylating agents. Furthermore, treatment with radiotherapy may drive acute and late adverse impacts on the lung. The major consequences of radiotherapy and chemotherapy in the lung are pneumonitis and fibrosis. Pneumonitis may arise some months to a few years behind cancer therapy. However, fibrosis is a long\u2010term effect that appears years after chemo\/or radiotherapy. Several mechanisms such as oxidative stress and severe immune reactions are implicated in the progression of pulmonary fibrosis. Epithelial\u2013mesenchymal transition (EMT) is offered as a pivotal mechanism for lung fibrosis behind chemotherapy and radiotherapy. It seems that pulmonary fibrosis is the main consequence of EMT after chemo\/radiotherapy. Several biological processes, consisting of the liberation of pro\u2010inflammatory and pro\u2010fibrosis molecules, oxidative stress, upregulation of nuclear factor of \u03baB and Akt, epigenetic changes, and some others, may participate in EMT and pulmonary fibrosis behind cancer therapy. In this review, we aim to discuss how chemotherapy or radiotherapy may promote EMT and lung fibrosis. Furthermore, we review potential targets and effective agents to suppress EMT and lung fibrosis after cancer therapy.<\/jats:p>","DOI":"10.1002\/jbt.23790","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T06:34:31Z","timestamp":1723012471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Epithelial\u2013mesenchymal transition in chemoradiation\u2010induced lung damage: Mechanisms and potential treatment approaches"],"prefix":"10.1002","volume":"38","author":[{"given":"Mohamed J.","family":"Saadh","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Middle East University Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1187-6768","authenticated-orcid":false,"given":"Pawan","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Sciences Jain (Deemed\u2010to\u2010be) University Bengaluru India"},{"name":"Department of Sciences Vivekananda Global University Jaipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israa Habeeb","family":"Naser","sequence":"additional","affiliation":[{"name":"Medical Laboratories Techniques Department AL\u2010Mustaqbal University Hillah Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Pharmacy\u2010Adarsh Vijendra Institute of Pharmaceutical Sciences Shobhit University Gangoh India"},{"name":"Department of Pharmacy Arka Jain University Jamshedpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ravi Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Raghu Engineering College Visakhapatnam Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irodakhon","family":"Rasulova","sequence":"additional","affiliation":[{"name":"Central Asian Center of Development Studies New Uzbekistan University Tashkent Uzbekistan"},{"name":"Department of Public Health Samarkand State Medical University Samarkand Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faraj","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratories technology Al\u2010Manara College for Medical Sciences (Maysan) Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer Qutaiba B.","family":"Allela","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Al\u2010Noor University College Nineveh Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wathiq Kh.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratories Technology Al\u2010Hadi University College Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahed Mahmood","family":"Ahmed","sequence":"additional","affiliation":[{"name":"College of Pharmacy National University of Science and Technology Nasiriyah Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Muzahem","family":"Al\u2010Ani","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratories Technology AL\u2010Nisour University College Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Huseen","family":"Redhee","sequence":"additional","affiliation":[{"name":"Medical Laboratory Technique College The Islamic University Najaf Iraq"},{"name":"Medical Laboratory Technique College The Islamic University of Al Diwaniyah Al Diwaniyah Iraq"},{"name":"Medical Laboratory Technique College The Islamic University of Babylon Babylon Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.07.491"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450111009011386"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.04.012"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753466620963866"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450123666220705123315"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450123666220907144131"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.04.019"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2016.12.004"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(01)00334-8"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03745-4"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.03.047"},{"key":"e_1_2_12_10_2","author":"Kong F.\u2010M.","year":"2005","journal-title":"presented at Seminars in oncology"},{"key":"e_1_2_12_10_3","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/480608"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-019-1449-z"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/13894501113149990198"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117570"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106663"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-018-01422-5"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123963"},{"key":"e_1_2_12_15_3","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.1478"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v6.i9.708"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2017.06.021"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2013.08.024"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000187"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.12.016"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01737-2017"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2018.1500180"},{"key":"e_1_2_12_21_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.07.1337"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-015-0619-x"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-020-02420-w"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/480608"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7113-8_2"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003273"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(03)00073-2"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0851"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.51445"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49026-y"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2213992043"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14254"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342046"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00380-2022"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyac118"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-22-1526"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2017.06.008"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.10.001"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.08.009"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e318240541e"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2464-0"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205582"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00333.x"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00353"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36183"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.104133"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071587"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.29245\/2689-999X\/2019\/2.1149"},{"key":"e_1_2_12_43_2","volume":"55","author":"Salton F.","year":"2019","journal-title":"Medicina (Kaunas)"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-204608"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-020-00264-1"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.01.013"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy0202.103268"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3182116e39"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-5-11"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2017.05.007"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201103-0516OC"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00011514"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-017-0654-2"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-014-0157-3"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2019-0328TR"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0273854"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-0977-2"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-015-0276-5"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.2217\/lmt.15.33"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-014-0112-1"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.75876"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2016.1247879"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.7573\/dic.2020-8-8"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450119666180207092234"},{"key":"e_1_2_12_62_1","doi-asserted-by":"crossref","unstructured":"D.Jiang J.Liang Vol. 200 American Thoracic Society 2019.","DOI":"10.1164\/rccm.201812-2313ED"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001605"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.4331\/wjbc.v7.i4.231"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207020"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyi126"},{"key":"e_1_2_12_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.10.065"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104745"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1494488"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2019-0071OC"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.05.136"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00163.2007"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00260"},{"key":"e_1_2_12_73_1","first-page":"372","volume":"345","author":"Cruz\u2010Solbes A. S.","year":"2017","journal-title":"Kidney development and disease"},{"key":"e_1_2_12_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24541"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radmp.2022.05.003"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0959-9673.2004.00377.x"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2855"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.10.423"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2014.323"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450111009011395"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2017-0088OC"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5818"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559325820968413"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3829"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13078293"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2013.07.008"},{"key":"e_1_2_12_85_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0131OC"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.2c00149"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.3.14709"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3138"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.336"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-3900"},{"key":"e_1_2_12_90_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2813"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39714"},{"key":"e_1_2_12_91_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553002.2016.1222094"},{"key":"e_1_2_12_91_3","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.5.2684"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154184"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1772-1"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf7532"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkac011"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2021.2010905"},{"key":"e_1_2_12_96_2","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-4-10"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-022-02038-x"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.876033"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070832"},{"key":"e_1_2_12_99_2","first-page":"733","volume":"11","author":"Zhong Y.","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"e_1_2_12_100_1","first-page":"733","volume":"11","author":"Zhong Y.","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.200900043"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28504"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901363"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.142"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068597"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2016-0259OC"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.003662"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2182-0"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2014.10.013"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0806-z"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011152"},{"key":"e_1_2_12_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112096"},{"key":"e_1_2_12_111_3","first-page":"331","volume":"46","author":"Zhang R.","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"e_1_2_12_111_4","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-015-0654-4"},{"key":"e_1_2_12_111_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2015.10.022"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2020.108699"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.03.056"},{"key":"e_1_2_12_113_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0319-3"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24398"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2013.153"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0240-4"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9111156"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4887-1"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-021-00894-9"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR13799.1"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2021.108952"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106761"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-022-04502-4"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106807"},{"key":"e_1_2_12_125_1","first-page":"27","author":"Zhao S.","year":"2022","journal-title":"Apoptosis"},{"key":"e_1_2_12_125_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13648"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-021-01689-7"},{"key":"e_1_2_12_126_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-022-01721-4"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000243"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2015.1016624"},{"key":"e_1_2_12_128_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200107000-00006"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-022-09762-6"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkac011"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011529"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-3193"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/232791"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11020183"},{"key":"e_1_2_12_134_2","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2014.0150"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1379521"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.03.015"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-1042-0"},{"key":"e_1_2_12_137_2","doi-asserted-by":"publisher","DOI":"10.3390\/life11010001"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36063-2"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.08.015"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1408418"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-017-0130-8"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1128\/ecosalplus"},{"key":"e_1_2_12_143_1","first-page":"16","volume":"1","author":"Zhang Y.","year":"2021","journal-title":"Histone Mutations and Cancer"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2014.03.001"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.5236"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acr.2017.06.003"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/320214"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.513"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.145"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.34380"},{"key":"e_1_2_12_150_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2015.08.003"},{"key":"e_1_2_12_150_3","first-page":"1","volume":"5","author":"Yin X.","year":"2015","journal-title":"Scientific reports"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.144453"},{"key":"e_1_2_12_151_2","first-page":"1855","volume":"41","author":"Chen J.","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"e_1_2_12_151_3","doi-asserted-by":"crossref","DOI":"10.1177\/0300060519882543","volume":"48","author":"Peng J.","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-95"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9TX00019D"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.152903"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-02024-7"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111309"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871523018666190319144020"},{"key":"e_1_2_12_157_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55080417"},{"key":"e_1_2_12_157_3","doi-asserted-by":"publisher","DOI":"10.2174\/1574884714666181214101917"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR2980.1"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.10.8.1571"},{"key":"e_1_2_12_159_2","first-page":"971","volume":"7","author":"Vigushin D. M.","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"e_1_2_12_159_3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20051162"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21664"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.09.037"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-021-00617-2"},{"key":"e_1_2_12_162_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15662"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24040708"},{"key":"e_1_2_12_163_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27010167"},{"key":"e_1_2_12_163_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110234"},{"key":"e_1_2_12_164_1","volume":"163","author":"Ghahremani H.","year":"2023","journal-title":"Acta Biochim. Iran."},{"key":"e_1_2_12_164_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.11.017"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-018-0466-0"},{"key":"e_1_2_12_165_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00419"},{"key":"e_1_2_12_165_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.05.104"},{"key":"e_1_2_12_166_1","first-page":"212","volume":"7","author":"Amini P.","year":"2018","journal-title":"Int. J. Mol. Cell Med."},{"key":"e_1_2_12_166_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871523018666190319144020"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2006.07.003"},{"key":"e_1_2_12_167_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00002.2009"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-06790-3"},{"key":"e_1_2_12_168_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2022.101953"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2020.1860242"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2014.10.015"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117290"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2016.1170804"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6312053"},{"key":"e_1_2_12_173_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17358-3"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.201012-071DW"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.15283\/ijsc16041"},{"key":"e_1_2_12_175_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-019-01101-2"},{"key":"e_1_2_12_175_3","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0776-6"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01926-x"},{"key":"e_1_2_12_176_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41576-5"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00430"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-022-02351-z"},{"key":"e_1_2_12_179_1","unstructured":"J.Liu X.Han M.Gu Q.Zhao Q.Li X.Liu 2024."},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-01017-w"},{"key":"e_1_2_12_180_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-023-09810-z"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v16.i6.670"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c10547"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-019-3019-6"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25092193"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5194780"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2020.113642"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c04996"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jeurceramsoc.2019.04.035"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00170-019-04534-z"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0566-2"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201902634"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.101174"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2019.04.075"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.08.012"},{"key":"e_1_2_12_194_2","doi-asserted-by":"publisher","DOI":"10.3390\/polym11020304"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.08.015"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104164"},{"key":"e_1_2_12_196_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1917508"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10311-020-01038-1"},{"key":"e_1_2_12_198_1","unstructured":"J.\u2010R.Lee B.\u2010W.Park J.Kim Y. W.Choo H. Y.Kim J.\u2010K.Yoon H.Kim J.\u2010W.Hwang M.Kang S. P.Kwon S. Y.Song I. O.Ko J.\u2010A.Park K.Ban T.Hyeon H.\u2010J.Park B.\u2010S.Kim Sci. Adv. n.d. 6 eaaz0952."},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2017-0037"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.08.023"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.3109\/10837450.2012.757782"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2015.08.009"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2015.993314"},{"key":"e_1_2_12_204_1","first-page":"1299","volume":"21","author":"Paudel K. R.","year":"2022","journal-title":"EXCLI J."},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1713"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2022.108165"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c03020"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13224036"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.7603\/s40730-015-0010-4"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.5812\/jjnpp.106961"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2105445"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.123117"},{"key":"e_1_2_12_213_1","first-page":"2","volume":"60","author":"Abouelella A.","year":"2022","journal-title":"Bull. Fac. Pharm. Cairo Univ."},{"key":"e_1_2_12_213_2","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2018.1560466"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2021.03.017"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/23\/50\/505101"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.06.024"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.04.147"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2018.01.012"},{"key":"e_1_2_12_219_1","author":"Gan C.","year":"2022","journal-title":"J. Adv. Res."},{"key":"e_1_2_12_220_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2012.39"},{"key":"e_1_2_12_221_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2011.559223"},{"key":"e_1_2_12_222_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw1237"},{"key":"e_1_2_12_223_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn7162"},{"key":"e_1_2_12_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.09.061"},{"key":"e_1_2_12_225_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6632160"},{"key":"e_1_2_12_226_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1552"},{"key":"e_1_2_12_227_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.742777"},{"key":"e_1_2_12_228_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg5358"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.23790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T08:53:11Z","timestamp":1732611191000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.23790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":287,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/jbt.23790"],"URL":"https:\/\/doi.org\/10.1002\/jbt.23790","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23790"}}