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In this study, we aimed to examine the protective effects of tannic acid (TA) against DOX\u2010induced hepatoxicity in experimental rat models. Rats were randomly divided into four experimental groups: the untreated control, DOX, TA, and cotreatment (DOX\u2009+\u2009TA) groups. We investigated the antioxidant system's main components and oxidative stress indicators. Moreover, we examined alterations in the mRNA expression of critical regulators that modulate apoptosis, inflammation, and cell metabolism to better understand the underlying factors of DOX\u2010induced liver toxicity. The results showed that DOX exposure caused an increase in MDA levels and a significant depletion of GSH content in rat liver tissues. Consistent with oxidative stress\u2010related metabolites, DOX was found to significantly suppress both mRNA expression and enzyme activities of antioxidant system components. Moreover, DOX exposure had significant adverse effects on regulating the other regulatory genes studied. However, it was determined that TA could alleviate many of the negative changes caused by DOX. The results of the present study indicated that TA might be considered a versatile candidate that could prevent DOX\u2010induced hepatotoxicity, possibly by preserving cell physiology, viability, and especially redox balance.<\/jats:p>","DOI":"10.1002\/jbt.23798","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T06:35:48Z","timestamp":1723012548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["The hepatoprotective potential of tannic acid against doxorubicin\u2010induced hepatotoxicity: Insights into its antioxidative, anti\u2010inflammatory, and antiapoptotic mechanisms"],"prefix":"10.1002","volume":"38","author":[{"given":"Neslihan","family":"\u00d6zturk","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Atat\u00fcrk University Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-4406","authenticated-orcid":false,"given":"Hamid","family":"Ceylan","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Atat\u00fcrk University Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-1098","authenticated-orcid":false,"given":"Yeliz","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, Nihat Delibalta Gole Vocational High School Ardahan University Ardahan T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201806_15270"},{"key":"e_1_2_11_3_1","first-page":"3","volume":"12","author":"Khan F. 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