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This study aims to investigate the effects of syringic acid (SA) on NAFLD in a high\u2010fat diet (HFD) rat model. Twenty\u2010four rats were randomly divided into four groups (<jats:italic>n<\/jats:italic>\u2009=\u20096): normal control, HFD, SA\u2010administered HFD, and positive control SA on a normal diet. Rats in the normal control and positive control groups received a normal diet, and the remaining groups received an HFD for 8 weeks. SA (20\u2009mg\/kg b.w.) was orally (gavage) administered for 8 weeks. Lipid profiles were controlled by SA against HFD\u2010fed rats (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). SA reduced the serum aspartate aminotransferase\u00a0and alanine aminotransferase\u00a0levels by 70%\u2013190%. SA also suppressed pro\u2010inflammatory cytokines\u00a0and attenuated histopathological and immunohistochemical changes against HFD\u2010fed rats. SA reversed oxidative stress by suppressing the malondialdehyde\u00a0formation by 82% and replenished the nonenzymatic and enzymatic antioxidant activities (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Gene expressions of nuclear factor\u2010erythroid 2\u2010related factor\/heme oxygenase 1 (Nrf2\/HO\u20101) were elevated in SA\u2010treated\u00a0rats. Ameliorative effects of SA on NAFLD induced by an HFD in rats were prominent through the reversal of oxidative stress and inflammation, regulated by an intrinsic mechanism of defense against oxidative stress, the Nrf2\/HO\u20101 pathway.<\/jats:p>","DOI":"10.1002\/jbt.23809","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T04:50:51Z","timestamp":1723783851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Protective effects of syringic acid in nonalcoholic fatty liver in rats through regulation of Nrf2\/HO\u20101 signaling pathway"],"prefix":"10.1002","volume":"38","author":[{"given":"Simiao","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine Hunan University of Traditional Chinese Medicine Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Third People's Hospital of Yunnan Province Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology Shaanxi Provincial Cancer Hospital Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Third People's Hospital of Yunnan Province Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhou","family":"Mao","sequence":"additional","affiliation":[{"name":"Graduate School of Clinical Medicine Dali University Dali Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate School of Clinical Medicine Dali University Dali Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Graduate School of Clinical Medicine Dali University Dali Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhiPeng","family":"Fu","sequence":"additional","affiliation":[{"name":"Graduate School of Clinical Medicine Dali University Dali Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Third People's Hospital of Yunnan Province Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7638-152X","authenticated-orcid":false,"given":"Long","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Shenzhen University General Hospital \u2013 Shenzhen University Clinical Medical Academy Shenzhen Guangdong China"},{"name":"Shenzhen University International Cancer Center Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0365"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16010115"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10020174"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2019-0487"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0367"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000366394"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2024.04.010"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14357"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.826204"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i42.7495"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15183888"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci85499"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1615\/jenvironpatholtoxicoloncol.2016013802"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2013.781194"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327119839173"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1402-71"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5fo01329a"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.33.983"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr752"},{"key":"e_1_2_10_21_1","first-page":"46","volume":"7","author":"Karthik G.","year":"2014","journal-title":"Asian J. 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