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Phloretin (PHL), biochanin\u2010A (BCA), and coenzyme Q10 (CoQ10) are bioactive compounds owning plentiful pharmacological properties. Henceforth, the current research explored the putative energizing effects of selected nutraceuticals in combined chromium (Cr) and arsenic (As) intoxicated <jats:italic>Swiss<\/jats:italic> albino mice. Potassium dichromate (75\u2009ppm) and sodium meta\u2010arsenite (100\u2009ppm) were given in the drinking water to induce hepatotoxicity, conjugated with PHL and BCA (50\u2009mg\/kg each), and CoQ10 (10\u2009mg\/kg) intraperitoneally for 2 weeks. After the statistical evaluation, it was observed that the hepato\u2010somatic index, metal load, and antioxidant activity (lipid peroxidation and protein carbonyl content) increased along with the concomitant decrease in the antioxidants (catalase, glutathione\u2010S\u2010transferase, superoxide dismutase, reduced glutathione, and total thiol) in the Cr and As intoxicated mice. Additionally, light microscopy observations, DNA breakages, decreased silent information regulator 1 (SIRT1), nuclear factor (erythroid\u2010derived 2)\u2010like 2 (Nrf2), heme oxygenase (HO\u20101), and NAD(P)H quinone dehydrogenase 1 (NQO1) gene expressions, together with stimulated apoptotic cell death manifested by the increased expressions of caspase 8 and caspase 3, thus, proved consistency with the aforementioned outcomes. Importantly, the treatment with nutraceuticals not only restored the antioxidant activity but also favorably altered the expressions of SIRT1, Nrf2, HO\u20101, and NQO1 signaling and apoptosis markers. These findings highlight the crucial role of the PHL, BCA, and CoQ10 combination in reducing Cr and As\u2010induced hepatotoxicity in mice. By averting the triggered apoptosis in conjunction with oxidative stress, this combination increases the SIRT1, Nrf2, HO\u20101, and NQO1 signaling, thereby reassuringly maintaining the cellular equilibrium.<\/jats:p>","DOI":"10.1002\/jbt.23817","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T11:33:59Z","timestamp":1724412839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Attenuation of chromium (VI) and arsenic (III)\u2010induced oxidative stress and hepatic apoptosis by phloretin, biochanin\u2010A, and coenzyme Q10 via activation of SIRT1\/Nrf2\/HO\u20101\/NQO1 signaling"],"prefix":"10.1002","volume":"38","author":[{"given":"Swapnil","family":"Tripathi","sequence":"first","affiliation":[{"name":"Toxicology Department ICMR\u2010National Institute of Occupational Health Ahmedabad Gujarat India"},{"name":"Department of Biochemistry &amp; Forensic Science Gujarat 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