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This study evaluated the protective effects of esculetin against DOX\u2010induced hepatotoxicity in rat livers. Forty\u2010eight rats were randomly divided into six groups with eight rats in each group: control (I), DOX (II), esculetin (III, 50\u2009mg\/kg), esculetin (IV, 100\u2009mg\/kg), DOX+esculetin 50 (V, DOX+esculetin 50\u2009mg\/kg), and DOX+esculetin 100 (VI, DOX+esculetin 100\u2009mg\/kg). The administration of esculetin effectively mitigated alterations in the measured biochemical parameters induced by DOX. Gene expression analyses demonstrated that esculetin treatment significantly reduced the DOX\u2010induced expression of <jats:italic>Foxo1, Hspa1a, Hsp4a, Hsp5a, Casp3,<\/jats:italic> and <jats:italic>Casp9<\/jats:italic> while increasing the DOX\u2010induced expression of <jats:italic>Foxo3<\/jats:italic>. These findings suggest that esculetin, with its antioxidant and anti\u2010inflammatory effects, might be a therapeutic option for protecting against DOX\u2010induced hepatotoxicity.<\/jats:p>","DOI":"10.1002\/jbt.23861","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T02:13:07Z","timestamp":1726884787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The protective effects of esculetin against Doxorubicin\u2010Induced hepatotoxicity in rats: Insights into the modulation of Caspase, FOXOs, and heat shock protein pathways"],"prefix":"10.1002","volume":"38","author":[{"given":"Duygu","family":"Kizir","sequence":"first","affiliation":[{"name":"Faculty of Science, Department of Molecular Biology and Genetics Atat\u00fcrk University Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra 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