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The current study aims to investigate the protective feature of carvacrol against sodium arsenite\u2010induced liver toxicity. Thirty\u2010five <jats:italic>Sprague\u2010Dawley<\/jats:italic> male rats were divided into five groups: Control, Sodium arsenite (SA), CRV, SA\u2009+\u2009CRV25, and SA\u2009+\u2009CRV50. Sodium arsenite was administered via oral gavage at a dose of 10\u2009mg\/kg for 14 days, and 30\u2009min later, CRV 25 or 50\u2009mg\/kg was administered via oral gavage. Oxidative stress, inflammation, apoptosis, autophagy damage pathways parameters, and liver tissue integrity were analyzed using biochemical, molecular, western blot, histological, and immunohistological methods. Carvacrol decreased sodium arsenite\u2010induced oxidative stress by suppressing malondialdehyde levels and increasing superoxide dismutase, catalase, glutathione peroxidase activities, and glutathione levels. Carvacrol reduced inflammation damage by reducing sodium arsenite\u2010induced increased levels of NF\u2010\u03baB and the cytokines (TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20106, RAGE, and NLRP3) it stimulates. Carvacrol also reduced sodium arsenite\u2010induced autophagic (Beclin\u20101, LC3A, and LC3B) and apoptotic (P53, Apaf\u20101, Casp\u20103, Casp\u20106, Casp\u20109, and Bax) parameters. Carvacrol preserved sodium arsenite\u2010induced impaired liver tissue structure. Carvacrol alleviated toxic damage by reducing sodium arsenite\u2010induced increases in oxidative stress, inflammation, apoptosis, and autophagic damage parameters in rat liver tissues. Carvacrol was also beneficial in preserving liver tissue integrity.<\/jats:p>","DOI":"10.1002\/jbt.23863","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T09:34:33Z","timestamp":1727256873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["The ameliorative effect of carvacrol on sodium arsenite\u2010induced hepatotoxicity in rats: Possible role of Nrf2\/HO\u20101, RAGE\/NLRP3, Bax\/Bcl\u20102\/Caspase\u20103, and Beclin\u20101 pathways"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-4146","authenticated-orcid":false,"given":"Selman","family":"Gencer","sequence":"first","affiliation":[{"name":"Department of Internal Diseases, Faculty of Medicine Aksaray University Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6775-7858","authenticated-orcid":false,"given":"Cihan","family":"G\u00fcr","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Techniques, Vocational School of Health Services Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4581-4492","authenticated-orcid":false,"given":"Mustafa","family":"\u0130lerit\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Horasan Vocational College Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8222-5515","authenticated-orcid":false,"given":"Sefa","family":"K\u00fc\u00e7\u00fckler","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biochemistry, Faculty of Veterinary Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8457-9448","authenticated-orcid":false,"given":"Nurhan","family":"Akaras","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Aksaray University Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5573-4923","authenticated-orcid":false,"given":"Hasan","family":"\u015eim\u015fek","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Aksaray University Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-2479","authenticated-orcid":false,"given":"Fatih M.","family":"Kandemir","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Aksaray University Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-020-08049-z"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110410"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2023.127154"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2019.1591434"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22890"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110649"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-020-11327-5"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2994"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13353"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23751"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120104"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2024.114791"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-018-1443-6"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.132009"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26226899"},{"key":"e_1_2_11_17_1","first-page":"1","author":"Dos Santos L. 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