{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:49:21Z","timestamp":1757540961065},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,6,8]],"date-time":"2006-06-08T00:00:00Z","timestamp":1149724800000},"content-version":"vor","delay-in-days":6308,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biochem. Toxicol."],"published-print":{"date-parts":[[1989,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ability of phenobarbital and \u03b2\u2010naphthoflavone to induce parathion desulfuration, aminopyrine <jats:italic>N<\/jats:italic>\u2010demethylation, and NADPH\u2013cyto\u2010chrome\u2010<jats:italic>c<\/jats:italic> reductase activity in the brain and liver of male and female rats was investigated. Activities of all three enzymes were found in similar levels in both the mitochondrial and microsomal fractions of brain. There were no sex differences in brain activities. Liver activities were from 10\u2010 to 30\u2010fold higher than brain activities when computed on a tissue\u2010wet\u2010weight\u2010equivalent basis. Although exposure to both inducers increased all three enzyme activities and cytochrome <jats:italic>P<\/jats:italic>\u2010450 in liver, neither inducer increased the enzyme activities in mitochondrial or microsomal brain fractions of either sex. Thus, these brain monooxygenase activities appear to be refractory to induction by two classical types of cytochrome <jats:italic>P<\/jats:italic>\u2010450 inducers. This lack of inducibility could serve to protect the animal against environmentally enhanced increases in the activation of xenobiotics to neurotoxic metabolites, such as parathion desulfuration to paraoxon.<\/jats:p>","DOI":"10.1002\/jbt.2570040111","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T01:27:56Z","timestamp":1161134876000},"page":"65-70","source":"Crossref","is-referenced-by-count":9,"title":["Lack of inducibility of brain monooxygenase activities including parathion desulfuration"],"prefix":"10.1002","volume":"4","author":[{"given":"Janice E.","family":"Chambers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol S.","family":"Forsyth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"99","volume-title":"Intermediary Xenobiotic Metabolism: Methodology, Mechanisms and Significance","author":"Chambers J. E.","year":"1989"},{"key":"e_1_2_1_3_2","unstructured":"C. S.ForsythandJ. E.Chambers(1989).Biochem. Pharmacol. in press."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(85)91638-9"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(85)90075-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90754-7"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90192-3"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(87)90142-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03189910"},{"key":"e_1_2_1_10_2","unstructured":"H. W.ChambersandJ. E.Chambers(1989).Pestic. Biochem. Physiol. in press."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(76)90170-2"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(85)90061-X"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"e_1_2_1_14_2","first-page":"203","volume":"4","author":"Litterst C. L.","year":"1976","journal-title":"Drug Metab. Disp."},{"key":"e_1_2_1_15_2","first-page":"565","volume-title":"Methods in Enzymology","author":"Masters B. S. S.","year":"1967"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)82245-5"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(88)90351-7"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(87)90190-0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(82)90158-2"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90243-0"}],"container-title":["Journal of Biochemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbt.2570040111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.2570040111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T04:22:25Z","timestamp":1697948545000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.2570040111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,3]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,3]]}},"alternative-id":["10.1002\/jbt.2570040111"],"URL":"https:\/\/doi.org\/10.1002\/jbt.2570040111","archive":["Portico"],"relation":{},"ISSN":["0887-2082","1522-7146"],"issn-type":[{"value":"0887-2082","type":"print"},{"value":"1522-7146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,3]]}}}