{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:35:50Z","timestamp":1791185750525,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,6,8]],"date-time":"2006-06-08T00:00:00Z","timestamp":1149724800000},"content-version":"vor","delay-in-days":6124,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biochem. Toxicol."],"published-print":{"date-parts":[[1989,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of the insecticides, mirex and chordecone (Kepone), on the cytochrome <jats:italic>P<\/jats:italic>\u2010450 monooxygenase system in C57BL\/6N mouse liver microsomes was studied. Mice were treated intraperitoneally with low (6 mg\/kg) and high (30 mg\/kg) doses of mirex and chlordecone in corn oil for 2 days. For comparison, mice were also treated with either phenobarbital (PB) or 3\u2010methylcholanthrene (3\u2010MC). All treatments significantly increased the hepatic microsomal <jats:italic>P<\/jats:italic>\u2010450 content over that of controls. Benzphetamine <jats:italic>N<\/jats:italic>\u2010demethylase, ethoxyresorufin <jats:italic>O<\/jats:italic>\u2010deethylase, benzo[<jats:italic>a<\/jats:italic>]pyrene hydroxylase, and acetanilide hydroxylase activities were also determined. Mirex and chlordecone resembled phenobarbital with respect to the induction of monooxygenase activities. Immunoquantitation with antibodies to purified <jats:italic>P<\/jats:italic>\u2010450 IIB1 (Pb\u2010induced <jats:italic>P<\/jats:italic>\u2010450) and <jats:italic>P<\/jats:italic>\u2010450 IA1 (3\u2010MC\u2010induced <jats:italic>P<\/jats:italic>\u2010450) indicated that mirex and chlordecone induced <jats:italic>P<\/jats:italic>\u2010450 IIB1 in a dose\u2010dependent manner. The high dose of mirex also induced a small amount of a protein cross reacting with the antibody to IA1. The induction of this isozyme did not, however, contribute significantly to the monooxygenase activities measured.<\/jats:p>","DOI":"10.1002\/jbt.2570040309","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T01:29:38Z","timestamp":1161134978000},"page":"195-199","source":"Crossref","is-referenced-by-count":15,"title":["Induction of cytochrome <i>p<\/i>\u2010450 isozymes by mirex and chlordecone"],"prefix":"10.1002","volume":"4","author":[{"given":"Margaret","family":"Lewandowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"Hodgson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(72)90043-6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(73)80023-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/00498258709047172"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/00498258709043995"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(76)90161-7"},{"key":"e_1_2_1_7_2","first-page":"3","volume-title":"Methods in Enzymology","author":"Galfre G.","year":"1981"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.22.040182.000513"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(78)90012-1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00901.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(83)90103-9"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01985747"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(62)05318-5"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"6242","DOI":"10.1016\/S0021-9258(18)94484-4","article-title":"Substrateinducible microsomal aryl hydroxylase in mammalian cell culture. 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