{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:59:09Z","timestamp":1772794749239,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,6,8]],"date-time":"2006-06-08T00:00:00Z","timestamp":1149724800000},"content-version":"vor","delay-in-days":5303,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biochem. Toxicol."],"published-print":{"date-parts":[[1991,12]]},"abstract":"Abstract<\/jats:title>Mercuric ion, a well\u2010known nephrotoxin, promotes oxidative tissue damage to kidney cells. One principal toxic action of Hg(II) is the disruption of mitochondrial functions, although the exact significance of this effect with regard to Hg(II) toxicity is poorly understood. In studies of the effects of Hg(II) on superoxide (O) and hydrogen peroxide (H2<\/jats:sub>O2<\/jats:sub>) production by rat kidney mitochondria, Hg(II) (1\u20136 \u03bcM), in the presence of antimycin A, caused a concentration\u2010dependent increase (up to fivefold) in mitochondrial H2<\/jats:sub>O2<\/jats:sub> production but an apparent decrease in mitochondrial O production. Hg(II) also inhibited O\u2010dependent cytochrome c reduction (IC50<\/jats:sub> \u2248\ufe012\u20133 \u03bcM) when O was produced from xanthine oxidase. In contrast, Hg(I) did not react with O in either system, suggesting little involvement of Hg(I) in the apparent dismutation of O by Hg(II). Hg(II) also inhibited the reactions of KO2<\/jats:sub> (i.e., O) with hemin or horseradish peroxidase dissolved in dimethyl sulfoxide (DMSO). Finally, a combination of Hg(II) and KO2<\/jats:sub> in DMSO resulted in a stable UV absorbance spectrum [currently assigned Hg(II)\u2010peroxide] distinct from either Hg(II) or KO2<\/jats:sub>. These results suggest that Hg(II), despite possessing little redox activity, enhances the rate of O dismutation, leading to increased production of H2<\/jats:sub>O2<\/jats:sub> by renal mitochondria. This property of Hg(II) may contribute to the oxidative tissue\u2010damaging properties of mercury compounds.<\/jats:p>","DOI":"10.1002\/jbt.2570060409","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T01:46:25Z","timestamp":1161135985000},"page":"293-298","source":"Crossref","is-referenced-by-count":45,"title":["Reactivity of Hg(II) with superoxide: Evidence for the catalytic dismutation of superoxide by HG(II)"],"prefix":"10.1002","volume":"6","author":[{"given":"Dennis M.","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert\u2010Ove","family":"Lund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0748-5514(85)90025-X"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0021-9258(19)68326-2","article-title":"Mitochondrial bioenergetics during the initiation of mercuric chloride induced renal injury. 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