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In this paper we have measured the effect of subacute i.p. administration on neutral and basic aminopepti\u2010dase activities in discrete zones of the rat brain using lysine\u2010 and leucine\u20102\u2010naphtylamides as substrates. Neutral aminopeptidase activity showed a significant decrease in the thalamus and cerebellum with marked (not significant) changes in the hypothalamus, hippocampus, medulla, and occipital cortex. There were no changes in basic ami\u2010nopeptidase activity. It is suggested that amino\u2010peptidase activity could play a role in carbon disulfide neurotoxic action in the aforementioned regions by generating changes in several neuropeptide levels.<\/jats:p>","DOI":"10.1002\/jbt.2570070306","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T01:51:25Z","timestamp":1161136285000},"page":"171-175","source":"Crossref","is-referenced-by-count":6,"title":["Regional distribution of neuropeptide\u2010degrading enzyme activity in the rat brain: Effects of subacute exposure to carbon disulfide"],"prefix":"10.1002","volume":"7","author":[{"given":"J. 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