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Both xenobiotics separately increase the liver :body weight ratio and their combined administration results in greater hepatomegaly than either compound alone. Both compounds induce NADPH\u2010cytochrome c(P450) reductase activity and laurate \u03c9\u2010 and \u03c9\u20101\u2010hydroxylase activities, but only phenobarbital induces pentoxyresorufin\u2010O\u2010de\u2010alkylase. None of the drug treatments induced microsomal cytochrome b5. Phenobarbital did not cause peroxisome proliferation and inhibited the corresponding clofibrate\u2010dependent proliferation. Taken collectively, our studies have demonstrated that concomitant treatment with phenobarbital and clofibrate are largely permissive with respect to the hepatic mixed function oxidase system but have opposing effects on the phenomenon of peroxisome proliferation in the same tissue.<\/jats:p>","DOI":"10.1002\/jbt.2570070309","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T01:51:25Z","timestamp":1161136285000},"page":"193-198","source":"Crossref","is-referenced-by-count":4,"title":["Influence of single and concurrent clofibrate and phenobarbital administration on cytochrome P450\u2010dependent mixed function oxidase activities and peroxisome proliferation in male rat liver"],"prefix":"10.1002","volume":"7","author":[{"given":"Ian","family":"Close","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth","family":"Shackleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Goldfarb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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