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Parameters for Fe<jats:sup>3+<\/jats:sup> ADP, NADPH or ascorbic acid\u2010initiated lipid peroxidation in vitro were measured. Approximately a twofold increase in susceptibility to lipid peroxidation was obtained for all the peroxisome proliferators tested. Cotreatment of mice with the peroxisome proliferator ASA (1%, w\/w) and a catalase inhibitor, 3\u2010amino\u20101,2,4\u2010triazole (AT; 0.4%, w\/w) for 7 days resulted in little inhibition of peroxisome proliferation, an elevated level of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> in vivo, and total inhibition of the increased susceptibility to lipid peroxidation in vitro. No increase in lipid peroxidation in vivo was observed. Certain antioxidant enzymes (DT\u2010diaphorase, superoxide dismutase, glutathione transferase, glutathione peroxidase, and glutathione reductase) and components (ubiquinone and \u03b1\u2010tocopherol) were also measured. The results showed that there was some induction of these antioxidant enzymes and components by ASA or aminotriazole, except for glutathione peroxidase and superoxide dismutase, which were inhibited. The possible involvement of oxidative stress in the carcinogenicity of peroxisome proliferators is discussed.<\/jats:p>","DOI":"10.1002\/jbt.2570100205","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T01:59:19Z","timestamp":1161136759000},"page":"87-94","source":"Crossref","is-referenced-by-count":34,"title":["Hepatic oxidative stress and related defenses during treatment of mice with acetylsalicylic acid and other peroxisome proliferators"],"prefix":"10.1002","volume":"10","author":[{"given":"Yanong","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eeva\u2010Liisa","family":"Appelkvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph W.","family":"Depierre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.6.2043"},{"key":"e_1_2_1_3_2","first-page":"585","article-title":"Review of the hepatic response to hypolipidemic drugs in rodents and assessment of its toxicological significance to man. 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