{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:04:49Z","timestamp":1788383089350,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Oral diseases are often associated with bacterial and fungal pathogens such as <jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>Streptococcus mutans<\/jats:italic>, <jats:italic>Enterococcus faecalis<\/jats:italic>, and <jats:italic>Candida albicans<\/jats:italic>. This research explored a novel approach to addressing these pathogens by synthesizing zinc oxide nanoparticles (ZnO NPs) coated with rutin (RT), a plant\u2010derived compound. The synthesized ZnO\u2010RT NPs were comprehensively characterized using UV\u2010Vis spectrophotometer, SEM, and EDAX techniques to confirm their structural composition. The antioxidant potential was assessed through free radical scavenging assays. Additionally, the antimicrobial activity of ZnO\u2010RT NPs was evaluated using a zone of inhibition assay against oral pathogens. Molecular docking studies with the Autodock tool were performed to elucidate the interactions between RT and the receptors of oral pathogens. The findings demonstrated that ZnO\u2010RT NPs exhibited robust free radical scavenging activity. Furthermore, they showed significant antimicrobial activity with a minimal inhibitory concentration of 40\u2009\u03bcg\/mL against oral pathogens. ZnO\u2010RT NPs also displayed dose\u2010dependent anticancer effects on human oral cancer cells at concentrations of 10, 20, 40, and 80\u2009\u03bcg\/mL. Mechanistic insights into the anticancer activity on KB cells revealed the upregulation of apoptotic genes. This study underscores the promising potential of ZnO\u2010RT NPs for dental applications due to their strong antioxidant, anticancer, and antimicrobial properties. These nanoparticles offer a hopeful prospect for addressing oral pathogen challenges and enhancing overall oral health.<\/jats:p>","DOI":"10.1002\/jbt.70030","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T12:14:59Z","timestamp":1730204099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Synergistic Action of Rutin\u2010Coated Zinc Oxide Nanoparticles: Targeting Biofilm Formation Receptors of Dental Pathogens and Modulating Apoptosis Genes for Enhanced Oral Anticancer Activity"],"prefix":"10.1002","volume":"38","author":[{"given":"Mohammed Rafi","family":"Shaik","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Science King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohankumar","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Engineering and Technology SRM Institute of Science and Technology, SRM Nagar, Kattankulathur Chengalpattu Tamil Nadu India"},{"name":"Interdisciplinary Institute of Indian System of Medicine SRM Institute of Science and Technology, SRM Nagar, Kattankulathur Chengalpattu Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Applied &amp; Life Sciences Uttaranchal University Dehradun Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kesavan","family":"Muthu","sequence":"additional","affiliation":[{"name":"Interdisciplinary Institute of Indian System of Medicine SRM Institute of Science and Technology Kattankulathur Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanitha","family":"Marunganathan","sequence":"additional","affiliation":[{"name":"Department of Cariology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrakumar","family":"Manivannan","sequence":"additional","affiliation":[{"name":"Division of Chemistry, Faculty of Engineering and Technology SRM Institute of Science and Technology Tiruchirapalli Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaik Althaf","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paramasivam","family":"Deepak","sequence":"additional","affiliation":[{"name":"Department of Life sciences Kristu Jayanti College (Autonomous) K. 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