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Forty\u2010two healthy female Wistar albino rats (250\u2013300\u2009g weight and 14\u201316 weeks) were randomly distributed into six equal groups (<jats:italic>n<\/jats:italic>\u2009=\u20097): control, cadmium 1\u2009mg (CD1), cadmium 5\u2009mg (CD5), ascorbic acid (AA), CD1+AA, CD5+AA. Cadmium was administered to pregnant rats by oral gavage every other day, and\/or AA (200\u2009mg) was administered every day. At the end of pregnancy (Day 21), blood, placenta, and fetuses were collected from rats. The results indicated that cadmium\u2010induced oxidative stress by increasing the level of MDA and by decreasing the levels of GSH, SOD, and CAT activity in the serum of maternal. However, AA administration significantly decreased MDA levels and increased GSH levels, SOD, and CAT activity (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Cadmium (5\u2009mg\/kg) exposure significantly increased creatinine levels compared to AA and CD1+AA groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In addition, AA (200\u2009mg\/kg) significantly attenuated cadmium\u2010induced histopathological alteration in the placental and fetal tissues. In conclusion, AA may prevent cadmium toxicity in maternal and fetal tissues, as it regulates oxidative imbalance in pregnant rat tissues and alleviates histopathological changes.<\/jats:p>","DOI":"10.1002\/jbt.70053","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T11:19:38Z","timestamp":1730891978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Protective Effects of Ascorbic Acid Against Cadmium\u2010Induced Toxicity in the Placenta and Fetus of Rats"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9994-1251","authenticated-orcid":false,"given":"Mehmet","family":"Ba\u015fe\u011fmez","sequence":"first","affiliation":[{"name":"Department of Veterinary, Laboratory and Veterinary Health Program, Acipayam Vocational High School Pamukkale University Denizli 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