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To this end, LPO was purified using the affinity chromatography technique with a yield of 12.63% (319.23\u2010fold). The results showed that the aromatic pyrazole compound (compound\n                    <jats:bold>1<\/jats:bold>\n                    ) containing 2,3\u2010dimethoxyphenyl functional groups was the most effective LPO inhibitor with a K\n                    <jats:sub>i<\/jats:sub>\n                    value of 3.2\u2009\u00b1\u20090.7\u2009nM and noncompetitive inhibition type. The second section of the study tested the previously synthesized compounds to reveal their antioxidant and antimicrobial properties. The above\u2010mentioned compound also displayed high activity levels compared to standard antibiotics and antifungals, while all other compounds also showed antibacterial activity. In the three antioxidant methods we used, the compound with 2,5\u2010dimethoxy phenyl groups obtained from the reaction of the aromatic pyrazole compound with propionic anhydride in the presence of NEt\n                    <jats:sub>3<\/jats:sub>\n                    displayed the highest activity. Furthermore, molecular docking and molecular mechanics studies were conducted to complement and validate the experimental findings. The results obtained from these computational analyses are highly consistent with the experimental data.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70055","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T13:40:56Z","timestamp":1731332456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Lactoperoxidase Inhibition of Celecoxib Derivatives Containing the Pyrazole Linked\u2010Sulfonamide Moiety: Antioxidant Capacity, Antimicrobial Activity, and Molecular Docking Studies"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6424-2760","authenticated-orcid":false,"given":"Song\u00fcl","family":"Bayrak","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science Ataturk University Erzurum 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