{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:58:14Z","timestamp":1792684694405,"version":"4.5.0"},"reference-count":190,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014361","name":"Hubei University of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014361","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The coexistence of Alzheimer's disease (AD) and chronic pain (CP) in the elderly population has been extensively documented, and a growing body of evidence supports the potential interconnections between these two conditions. This comprehensive review explores the mechanisms by which CP may contribute to the development and progression of AD, with a particular focus on neuroinflammatory pathways and the role of microglia, as well as the activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome. The review proposes that prolonged pain processing in critical brain regions can dysregulate the activity of the NLRP3 inflammasome within microglia, leading to the overproduction of pro\u2010inflammatory cytokines and excessive oxidative stress in these regions. This aberrant microglial response also results in localized neuroinflammation in brain areas crucial for cognitive function. Additionally, CP as a persistent physiological and psychological stressor may be associated with hypothalamic\u2010pituitary\u2010adrenal (HPA) axis dysfunction, systemic inflammation, disruption of the blood\u2013brain barrier (BBB), and neuroinflammation. These pathophysiological changes can cause morphological and functional impairments in brain regions responsible for cognition, memory, and neurotransmitter production, potentially contributing to the development and progression of CP\u2010associated AD. Resultant neuroinflammation can further promote amyloid\u2010beta (A\u03b2) plaque deposition, a hallmark of AD pathology. Potential therapeutic interventions targeting these neuroinflammatory pathways, particularly through the regulation of microglial NLRP3 activation, hold promise for improving outcomes in individuals with comorbid CP and AD. However, further research is required to fully elucidate the complex interplay between these conditions and develop effective treatment strategies.<\/jats:p>","DOI":"10.1002\/jbt.70071","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:47:34Z","timestamp":1737679654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Role of NLRP3 Inflammasome in Chronic Pain and Alzheimer's Disease\u2014A Review"],"prefix":"10.1002","volume":"39","author":[{"given":"Fatemeh","family":"Moradi","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Neuroscience Rowan University School of Osteopathic Medicine Stratford New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4126-7102","authenticated-orcid":false,"given":"Tahmineh","family":"Mokhtari","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Basic Medical Sciences Hubei University of Medicine Shiyan People's Republic of China"},{"name":"Department of Entomology and Nematology, UC Davis Comprehensive Cancer Center University of California Davis Davis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0029857"},{"key":"e_1_2_15_3_1","volume-title":"Social & Public Policy of Alzheimer's Disease in the United States","author":"Blank R. H.","year":"2018"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70072-2"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(03)00145-3"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S303186"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2016.1218543"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.06.009"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444791"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-28418-1"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.59.8.795"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110520"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3516"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-019-0111-7"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.12.078"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1608-z"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.01.002"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000403"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12672"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12734"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040822"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2021.638007"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4397"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.458901"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.570711"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2016.12.004"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2017.09.002"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2021.105737"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-014-2100-2"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12079"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10800"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000313"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00457-2"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2018.06.009"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2006.00079.x"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205016666181212162424"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.05.021"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317513517046"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-016-0342-7"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.53"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000534"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.06.005"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1003"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.8.11.1691"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1304"},{"issue":"4","key":"e_1_2_15_46_1","first-page":"601","article-title":"Microstructural Abnormalities in Gray Matter of Patients With Postherpetic Neuralgia: A Diffusional Kurtosis Imaging Study","volume":"19","author":"Zhang Y.","year":"2016","journal-title":"Pain physician"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.26599\/BSA.2019.9050025"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2541-04.2004"},{"issue":"1","key":"e_1_2_15_49_1","first-page":"184","article-title":"Herpes Zoster Chronification to Postherpetic Neuralgia Induces Brain Activity and Grey Matter Volume Change","volume":"10","author":"Cao S.","year":"2018","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00123"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.04.011"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1331.2001.00727.x"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12750"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00043"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00430"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.114287"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2012.03.003"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488507780619086"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043386473"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.05.057"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.06.033"},{"issue":"3","key":"e_1_2_15_62_1","first-page":"1149","article-title":"Noradrenergic Fiber Sprouting and Altered Transduction in Neuropathic Prefrontal Cortex","volume":"223","author":"Cordeiro Matos S.","year":"2018","journal-title":"Brain Structure & Function"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23956"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1608-z"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2024.114652"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01707-3"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glae206"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2797-06.2006"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.02.013"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.6.846"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2019.08.007"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.11.023"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.270297"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02489-9"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105311"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.28.061604.135709"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2016.04.001"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210191"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.01.003"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq362"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20021007"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.601519"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12750"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01235-5"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320510"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.03.001"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00063"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S75546"},{"issue":"10","key":"e_1_2_15_89_1","first-page":"136","article-title":"Role of Pro\u2010Inflammatory Cytokines Released From Microglia in Alzheimer's Disease","volume":"3","author":"Wang W.\u2010Y.","year":"2015","journal-title":"Annals of Translational Medicine"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.12.019"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf8924"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4334"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107581"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-020-00563-w"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239036"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.01.001"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.879021"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-020-05610-z"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107364"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.272576"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26040953"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105482"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2009.05.006"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.661838"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13139"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-009-9164-4"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.871997"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.701282"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001832"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4018"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.22317\/jcms.v6i1.735"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00314"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0055-7"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2014.01.008"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww017"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22295"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv379"},{"issue":"10","key":"e_1_2_15_118_1","first-page":"136","article-title":"Role of Pro\u2010Inflammatory Cytokines Released From Microglia in Alzheimer's Disease","volume":"3","author":"Wang W. Y.","year":"2015","journal-title":"Annals of Translational Medicine"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294609"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06616"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0518-0"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00181-0"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12386"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0616-08.2008"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205018666211105140732"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-012-0181-2"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.1072"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)03176-0"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21212"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1159\/000068322"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.04.025"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8430123"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-3-5"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.09.009"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1636"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3MR0416-204R"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.09.002"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11729"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.24903"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04516"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-020-03121-z"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.016"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-73"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00213"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP085714"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.11.009"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0003-06.2006"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06955.x"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00213"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2235-16.2016"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2018.2"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu377"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.09.018"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2017.05.010"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004063"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00209"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.06.015"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.1177\/1744806916646784"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23883"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002130"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00220"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.05.025"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-28418-1"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-020-09437-5"},{"key":"e_1_2_15_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.05.020"},{"issue":"12","key":"e_1_2_15_166_1","first-page":"493","article-title":"Clinically Relevant Late\u2010Life Depression as Risk Factor of Dementia: A Systematic Review and Meta\u2010Analysis of Prospective Cohort Studies","volume":"68","author":"Santabarbara J.","year":"2019","journal-title":"Revista de Neurologia"},{"key":"e_1_2_15_167_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.112.118307"},{"key":"e_1_2_15_168_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-007-9385-y"},{"key":"e_1_2_15_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.10.022"},{"key":"e_1_2_15_170_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23311"},{"key":"e_1_2_15_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109916"},{"key":"e_1_2_15_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03072-x"},{"key":"e_1_2_15_173_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.845185"},{"key":"e_1_2_15_174_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0467-9"},{"key":"e_1_2_15_175_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210400"},{"key":"e_1_2_15_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114464"},{"key":"e_1_2_15_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301377"},{"key":"e_1_2_15_178_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666160203142111"},{"key":"e_1_2_15_179_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330363"},{"key":"e_1_2_15_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.02.149"},{"key":"e_1_2_15_181_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1211-9"},{"key":"e_1_2_15_182_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400305"},{"key":"e_1_2_15_183_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-014-1647-2"},{"key":"e_1_2_15_184_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S292824"},{"key":"e_1_2_15_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-45220-1"},{"key":"e_1_2_15_186_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S228577"},{"key":"e_1_2_15_187_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5052"},{"key":"e_1_2_15_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2017.05.014"},{"key":"e_1_2_15_189_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1714"},{"key":"e_1_2_15_190_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203274"},{"key":"e_1_2_15_191_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyaa076"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70071","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.70071","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:28:08Z","timestamp":1780338488000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.70071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,23]]},"references-count":190,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/jbt.70071"],"URL":"https:\/\/doi.org\/10.1002\/jbt.70071","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,23]]},"assertion":[{"value":"2024-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70071"}}