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Increased oxidative stress, mitochondrial dysfunction, and neuroinflammation are common features of Alzheimer's disease (AD) and Parkinson's disease (PD). Silent information regulator 1 (SIRT\u20101), part of the sirtuin family, plays a critical role in various physiological processes by binding to histones and nonhistone proteins. SIRT\u20101 primarily mitigates oxidative stress and regulates mitochondrial activity by maintaining the deacetylated form of peroxisome proliferator\u2010activated receptor\u2010\u03b3 coactivator\u20101\u03b1 (PGC\u20101\u03b1), ensuring stable PGC\u20101\u03b1 levels. Research has shown reduced SIRT\u20101\/PGC\u20101\u03b1 expression in AD and PD models. Targeting this pathway presents a promising therapeutic approach for managing AD and PD, potentially leading to disease\u2010modifying treatments and improved outcomes. This review highlights the findings of various studies suggesting that the SIRT\u20101\/PGC\u20101\u03b1 pathway promotes mitochondrial biogenesis, synaptic plasticity, and cognitive function, as well as exerts antioxidant, anti\u2010inflammatory, and anti\u2010apoptotic effects, offering a potential method for AD and PD treatment.<\/jats:p>","DOI":"10.1002\/jbt.70078","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T06:41:30Z","timestamp":1733121690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Silent Information Regulator 1\/Peroxisome Proliferator\u2010Activated Receptor\u2010\u03b3 Coactivator\u20101\u03b1 Axis: A Promising Target for Parkinson's and Alzheimer's Disease 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