{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:50:01Z","timestamp":1792018201036,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acute kidney injury (AKI) is one of the leading causes of chronic kidney disease and accounts for 50%\u201375% of mortality following renal pathologies or organ transplantation. Ischemia\u2012reperfusion injury (IRI) involves an interrupted blood supply to organs and the kidney; IRI exacerbates AKI development. Owing to several pharmacological treatment methods, AKI still has a poor prognosis, and novel therapeutic options are needed. Agomelatine (AGM) is a melatonin receptor agonist (MT1 and MT2) with increased bioavailability and lipophilicity. In this study, we aimed to investigate the antioxidant and anti\u2010inflammatory effects of AGM in experimental renal IRI via long\u2010term and short\u2010term applications. Sixty male Sprague\u2013Dawley rats were randomly divided into six groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910): the control, I\/R, AGM20S, AGM40S, AGM20L, and AGM40L groups. Following the establishment of the renal IRI model, the rats received agomelatine at 20 and 40\u2009mg\/kg orally, and agomelatine solvent (hydroxyethylcellulose) was used as a vehicle. At the end of the experiment, blood samples and renal tissues were harvested for histopathological and biochemical analysis. Urea, creatinine, tumor necrosis factor (TNF\u2010\u03b1), and interleukin\u20101 beta (IL\u20101\u03b2) levels were measured in blood serum samples. Malondialdehyde (MDA) levels and increased superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), and total glutathione (GSH) levels were measured in renal tissue supernatants. Our biochemical results indicated that AGM reduced creatinine, TNF\u2010\u03b1, IL\u20101\u03b2, and malondialdehyde levels and increased SOD, CAT, GSHPx, and total GSH levels. Agolematine reduced infiltration, intratubular hemorrhage, and intratubular cast formation histopathologically. Our results suggest that AGM could be a potential therapeutic adjuvant agent for ischemia\u2012reperfusion injury in the kidney and several other organs.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70090","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T06:46:18Z","timestamp":1733813178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An Experimental Insight Into the Role of Agomelatine in Renal Ischemia\/Reperfusion Injury"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6094-4754","authenticated-orcid":false,"given":"Damla","family":"Aykora","sequence":"first","affiliation":[{"name":"Vocational School of Health Sciences Bitlis Eren University Bitlis Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Refik","family":"Bahar","sequence":"additional","affiliation":[{"name":"Nutritional Health Sciences Osmaniye Korkut Ata University Osmaniye Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevser","family":"Tanbek","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine \u0130n\u00f6n\u00fc University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilara Altay","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Turgut \u00d6zal University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine \u0130n\u00f6n\u00fc University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fcleyman","family":"Sandal","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine \u0130n\u00f6n\u00fc University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2757-1802","authenticated-orcid":false,"given":"Suat","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine \u0130n\u00f6n\u00fc University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/AJPRENAL.00392.2021\/ASSET\/IMAGES\/LARGE\/AJPRENAL.00392.2021_F008.JPEG"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/THNO.70830"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.INTIMP.2021.108393"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CLNESP.2022.01.038"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS12060838"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/JPI.12535"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/FASEBJ.2022.36.S1.0R423"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S2175-97902022E20957"},{"key":"e_1_2_12_10_1","first-page":"81","article-title":"Protective Effects of Agomelatin, a Melatonin Receptor Agonist, on Paracetamol Induced Nephrotoxicity","volume":"39","author":"Kartal N. T.","year":"2019","journal-title":"Hacettepe University Journal of the Faculty of Pharmacy"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-023-02632-0"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EJPHAR.2015.11.054"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.33549\/PHYSIOLRES.935064"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12974-022-02479-X"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2020.1715442"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.14260\/JEMDS\/2015\/1235"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10753-011-9318-4"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.3.497"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-091302-2.50032-3"},{"key":"e_1_2_12_20_1","first-page":"158","article-title":"Studies on the Quantitative and Qualitative Characterization of Erythrocyte Glutathione Peroxidase","volume":"70","author":"Paglia D. E.","year":"1967","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90342-1"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCRC.2010.03.006"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00284-z"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016020177"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/AJPRENAL.00557.2012"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02025"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CYTO.2019.154957"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0B013E3182439613"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2015.1011550"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(95)03570-2"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NUMECD.2005.05.003"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70090","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.70090","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:59:35Z","timestamp":1774342775000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.70090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/jbt.70090"],"URL":"https:\/\/doi.org\/10.1002\/jbt.70090","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70090"}}