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This study aimed to evaluate the chemoprotective efficacy of Cyanidin\u20103\u2010glucoside (C3G) in a rat model of CRC induced by 1,2\u2010dimethylhydrazine (DMH). Rats were stratified into groups and administered C3G at doses of 10 and 15\u2009mg\/kg following DMH exposure to initiate CRC. Key parameters, including organ weights, tumor burdens, and biochemical markers, were meticulously assessed. Administration of C3G significantly restored body weight while reducing the weights of colon and spleen tissues. Moreover, C3G treatment substantially suppressed tumor incidence and weight in DMH\u2010induced CRC rats. Biochemical analysis revealed that C3G markedly reduced levels of CFA, CA19.9, LDH, and nitric oxide (NO). It also modulated lipid profiles, antioxidant activities, and the expression of both Phase I and II enzymes. Inflammatory mediators, including TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20101\u03b1, IL\u20102, IL\u20104, IL\u20106, IL\u201010, IL\u201012, and IL\u201017, were significantly downregulated. Notably, C3G inhibited inflammatory markers such as COX\u20102, PGE2, iNOS, and NF\u2010\u03baB while promoting Caspase\u20103, \u20106, and \u20109 activity. Furthermore, it regulated the Bax\/Bcl\u20102 apoptotic axis, reducing the Bcl\u20102\/Bax ratio. Cyanidin\u20103\u2010glucoside demonstrated potent chemopreventive effects against colorectal cancer in this experimental model. Its mechanism of action is likely mediated through modulation of NF\u2010\u03baB and the Bcl\u20102\/Bax\/Caspase pathway, suggesting its potential as a therapeutic agent in CRC management.<\/jats:p>","DOI":"10.1002\/jbt.70125","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T23:40:37Z","timestamp":1737589237000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chemoprotective Potential of Cyanidin\u20103\u2010Glucoside Against 1,2\u2010Dimethylhydrazine\u2010Induced Colorectal Cancer: Modulation of NF\u2010\u03baB and Bcl\u20102\/Bax\/Caspase Pathway"],"prefix":"10.1002","volume":"39","author":[{"given":"Miao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The Second Hospital of Heilongjiang Province Harbin City Heilongjiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1770-6486","authenticated-orcid":false,"given":"Xiaoyong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Second Hospital of Heilongjiang Province Harbin City Heilongjiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X21500385"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092025"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101174"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2020.08.004"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284820917527"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010143"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.111981"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.9.4393"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.05.001"},{"key":"e_1_2_12_11_1","first-page":"54","article-title":"Methanolic Extract of Terminalia chebula Protects Against DMH Induced Colon Damage in Wistar Rats by Restoring Antioxidant Enzyme Activities and Suppressing Inflammation","volume":"6","author":"Hamiza O. 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