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In this paper, we scrutinized the effects and molecular mechanisms of the IRIS on CIS\u2010induced liver and kidney damage in mice. IRIS administration alleviated CIS\u2010induced elevations in AST, ALT, ALP, BUN, and creatinine levels by approximately 12%, 15%, 11%, 21%, and 15%, respectively. It also inhibited liver and kidney MDA levels by approximately 29% and 28%, while enhancing liver and kidney GSH, SOD, and CAT levels by 47%\u201360%, 85%\u201370%, and 90%\u201355%, respectively. IRIS enhanced liver and kidney mRNA expression levels of Nrf2 (by approximately 1.6\u2010 and 1.5\u2010fold, respectively), HO\u20101 (by 1.5\u2010 and 1.5\u2010fold, respectively), and Bcl\u20102 (by 1.5\u2010 and 1.4\u2010fold, respectively). In addition, IRIS suppressed the mRNA expression levels of NF\u2010\u03baB (by 0.7\u2010 and 0.7\u2010fold), TNF\u2010\u03b1 (by 0.7\u2010 and 0.7\u2010fold), Bax (by 0.8\u2010 and 0.7\u2010fold), and Cas\u20103 (by 0.9\u2010 and 0.7\u2010fold). Protein expression analysis revealed that IRIS increased Nrf2 (by 1.5\u2010 to 1.2\u2010fold) and Bcl\u20102 levels (by 1.3\u2010 to 1.7\u2010fold), and reduced Bax (by 0.7\u2010 to 0.8\u2010fold) and Cas\u20103 (by 0.8\u2010 and 0.8\u2010fold) levels altered by CIS treatment. Moreover, IRIS administration prevented histopathological changes in the liver and kidney caused by CIS. Ultimately, IRIS was found to substantially mitigate CIS\u2010induced hepatorenal injury by targeting oxidative stress, inflammation, and apoptosis through regulation of the Nrf2\/HO\u20101 signaling pathway. Therefore, IRIS holds potential as a therapeutic adjuvant in the use of CIS.<\/jats:p>","DOI":"10.1002\/jbt.70136","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T09:15:23Z","timestamp":1736327723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Iristectorin A Ameliorates Cisplatin\u2010Induced Hepatorenal Injury in Mice Through Modulation of the Nrf2\/HO\u20101 Signaling Pathway"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1414-4115","authenticated-orcid":false,"given":"Berrin","family":"Yalinbas\u2010Kaya","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Ministry of Health Eskisehir City Hospital Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Tureyen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ministry of Health Eskisehir City Hospital Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selcan","family":"Cesur","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ministry of Health Eskisehir City Hospital Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahriye","family":"Zemheri\u2010Navruz","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Faculty of Science Bart\u0131n University Bart\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan H.","family":"Demirel","sequence":"additional","affiliation":[{"name":"Bayat Vocational School Afyon Kocatepe University Afyonkarahisar Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"Ince","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Afyon Kocatepe University Afyonkarahisar Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOORG.2019.102925"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.M707568200\/ASSET\/2C805BFC-2454-4A4E-A2FC-4B760B544257\/MAIN.ASSETS\/GR10.JPG"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-1010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00631-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28186463"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2020.1808671"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.LFS.2021.119485"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CBI.2013.12.005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/JCMM.17968"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxres\/tfae129"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27227815"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SEPPUR.2011.01.017"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHYTOCHEM.2007.02.018"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JPBA.2015.05.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i15.1753"},{"issue":"1","key":"e_1_2_9_17_1","first-page":"64","article-title":"[Analysis of Isoflavones in Belamcanda chinensis (L.)DC. and Iris tectorum Maxim by Square Wave Voltammetry]","volume":"27","author":"Wu Y. 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