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Given the indeterminate nature of cancer etiology, the importance of drugs capable of targeting multiple pathways cannot be overstated. Among naturally occurring compounds, bisbenzylisoquinoline (BBIQ) alkaloids, such as berberine, tetrandrine, chelidonine, and berbamine, have demonstrated significant anticancer potential by modulating diverse signaling pathways. Several of these compounds are currently in clinical trials, highlighting their relevance in cancer treatment. This review emphasizes the need for further investigation into the anticancer properties of BBIQ alkaloids, particularly those isolated from eight\n                    <jats:italic>Cyclea<\/jats:italic>\n                    species in India. With around 27 BBIQ alkaloids identified, these compounds hold promise, especially in combating multidrug resistance\u2014a critical challenge in cancer therapy. Given the rising cancer incidence, these alkaloids warrant a deeper exploration of their therapeutic potential.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70137","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T06:08:24Z","timestamp":1737439704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Comprehensive Appraisal of Bisbenzylisoquinoline Alkaloids Isolated From Genus\n                    <i>Cyclea<\/i>\n                    for Anticancer Potential"],"prefix":"10.1002","volume":"39","author":[{"given":"Alisha","family":"Valsan","sequence":"first","affiliation":[{"name":"Chemical Sciences and Technology Division CSIR\u2010National Institute for Interdisciplinary Science and Technology (CSIR\u2010NIIST) Thiruvananthapuram India"},{"name":"Academy of Scientific and Innovative Research (AcSIR) Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu K.","family":"Omanakuttan","sequence":"additional","affiliation":[{"name":"Chemical Sciences and Technology Division CSIR\u2010National Institute for Interdisciplinary Science and Technology (CSIR\u2010NIIST) Thiruvananthapuram India"},{"name":"Academy of Scientific and Innovative Research (AcSIR) Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kokuvayil Vasu","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Chemical Sciences and Technology Division CSIR\u2010National Institute for Interdisciplinary Science and Technology (CSIR\u2010NIIST) Thiruvananthapuram India"},{"name":"Academy of Scientific and Innovative Research (AcSIR) Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3368-6929","authenticated-orcid":false,"given":"Kaustabh Kumar","family":"Maiti","sequence":"additional","affiliation":[{"name":"Chemical Sciences and Technology Division CSIR\u2010National Institute for Interdisciplinary Science and Technology (CSIR\u2010NIIST) Thiruvananthapuram India"},{"name":"Academy of Scientific and Innovative Research (AcSIR) Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0000315"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27072165"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-43175-x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.891652"},{"key":"e_1_2_8_8_1","first-page":"1","volume-title":"The Alkaloids","author":"Barbosa\u2010Filho J.","year":"2000"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26237368"},{"key":"e_1_2_8_10_1","unstructured":"WFO\u2014The World Flora Online. 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