{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:51:06Z","timestamp":1788922266016,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Ischemia\u2010reperfusion (I\/R) injury is a significant clinical problem impacting the heart and other organs, such as the kidneys and liver. This study explores the protective effects of oxycodone on myocardial I\/R injury and its underlying mechanisms. Using a myocardial I\/R model in Sprague\u2010Dawley (SD) rats and an oxygen\u2010glucose deprivation\/reoxygenation (OGD\/R) model in H9c2 cells, we administered oxycodone and inhibited AMP\u2010activated protein kinase (AMPK) with Compound C (C.C). Our results showed that oxycodone significantly reduced lactate dehydrogenase (LDH) release and reactive oxygen species (ROS) production while stabilizing mitochondrial membrane potential (MMP). Western blot and RT\u2010qPCR analyzes confirmed that oxycodone enhances AMPK phosphorylation and upregulates the expression of Silent Information Regulator 1 (SIRT1) and Peroxisome Proliferator\u2010Activated Receptor \u03b3 Coactivator 1\u03b1 (PGC\u20101\u03b1), thereby protecting myocardial cells. These findings suggest that oxycodone exerts significant protective effects against I\/R injury by activating the AMPK pathway, offering new potential therapeutic targets for myocardial protection.<\/jats:p>","DOI":"10.1002\/jbt.70151","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T02:50:33Z","timestamp":1737946233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Protective Role of Oxycodone in Myocardial Oxidative Stress and Mitochondrial Dysfunction Induced by Ischemia\u2010Reperfusion"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-8999","authenticated-orcid":false,"given":"Yongzheng","family":"Jiang","sequence":"first","affiliation":[{"name":"The People's Hospital of Jiawang District of Xuzhou City Xuzhou 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